LOCUS       NM_001180072            1860 bp    mRNA    linear   PLN 15-SEP-2023
DEFINITION  Saccharomyces cerevisiae S288C SUMO-targeted ubiquitin ligase
            complex subunit SLX5 (SLX5), partial mRNA.
ACCESSION   NM_001180072
VERSION     NM_001180072.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1860)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1860)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1860)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1860)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 1860)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 1860)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001136).
            
            On Jul 30, 2012 this sequence version replaced NM_001180072.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     gene            <1..>1860
                     /gene="SLX5"
                     /locus_tag="YDL013W"
                     /gene_synonym="HEX3; ULS2"
                     /db_xref="GeneID:851549"
     CDS             1..1860
                     /gene="SLX5"
                     /locus_tag="YDL013W"
                     /gene_synonym="HEX3; ULS2"
                     /EC_number="2.3.2.27"
                     /experiment="EXISTENCE:direct assay:GO:0000775 chromosome,
                     centromeric region [PMID:23785440]"
                     /experiment="EXISTENCE:direct assay:GO:0004842
                     ubiquitin-protein transferase activity
                     [PMID:17728242|PMID:17848550|PMID:18032921]"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:19270524|PMID:23785440]"
                     /experiment="EXISTENCE:direct assay:GO:0016567 protein
                     ubiquitination
                     [PMID:17728242|PMID:17848550|PMID:18032921|PMID:26906737]"
                     /experiment="EXISTENCE:direct assay:GO:0032183 SUMO
                     binding [PMID:17848550]"
                     /experiment="EXISTENCE:direct assay:GO:0033768
                     SUMO-targeted ubiquitin ligase complex [PMID:17848550]"
                     /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA
                     damage response [PMID:11139495]"
                     /experiment="EXISTENCE:genetic interaction:GO:0016567
                     protein ubiquitination [PMID:26906737]"
                     /experiment="EXISTENCE:genetic interaction:GO:0016925
                     protein sumoylation [PMID:16387868]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000723
                     telomere maintenance [PMID:16428246]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006511
                     ubiquitin-dependent protein catabolic process
                     [PMID:26960795]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006915
                     apoptotic process [PMID:31320817]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
                     damage response [PMID:11139495|PMID:16325482]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
                     ubiquitination [PMID:26906737]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein
                     sumoylation [PMID:16387868]"
                     /experiment="EXISTENCE:physical interaction:GO:0032183
                     SUMO binding [PMID:17728242]"
                     /note="Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase
                     (STUbL) complex; role in Ub-mediated degradation of
                     histone variant Cse4p preventing mislocalization to
                     euchromatin; role in proteolysis of spindle positioning
                     protein Kar9p, and DNA repair proteins Rad52p and Rad57p;
                     forms SUMO-dependent nuclear foci, including DNA repair
                     centers; contains a RING domain and two SIM motifs;
                     associates with the centromere; required for maintenance
                     of genome integrity like human ortholog RNF4"
                     /codon_start=1
                     /product="SUMO-targeted ubiquitin ligase complex subunit
                     SLX5"
                     /protein_id="NP_010271.3"
                     /db_xref="GeneID:851549"
                     /db_xref="SGD:S000002171"
                     /translation="

MHSDTNGRTKSNNSPSDNNPNETVILIDSDKEEDASIREANLPVRLYPDRRVGRRRDALNRFVRSDSRSRNSQRTHITASSERPDFQANNDDITIIREVGRFFGDDGPIDPSAHYVDLDQEPGSETLETPRTIQVDNTNGYLNDNGNNNESDDGLTIVEERTTRPRVTLNLPGGERLEVTATTTDIPIRRSFEFQEDLGASRRQLLRRSATRARNLFVDRSDENDEDWTDDTHNLPEAIQRARRESRMRMSRRIAERQRRVQQQRVSSDENISTSIRLQSIRERIQSYTPDIRSAFHRAESLHEFRSILQNVAPITLQECEEELMALFTEFRNQLLQNWAIDRVRNTQEEALRLHREALERQERTAGRVFHRGTLRESITNYLNFNGEDGFLSRLWSGPALSDADEERHTQNIIDMIQEREERERDVVMKNLMNKTRAQQEEFEARAASLPEGYSASFDTTPKMKLDITKNGKEETIIVTDDDLAKTLEDIPVCCLCGAELGVGIPDDFTGISQKDRGVSFEGLVSKYKFHCPYQTLARPSMLDRDLSKRTFIASCGHAFCGRCFARIDNAKKKSKMPKKKLAQLKGSAHPDNYGPKLCPADSCKKLIRSRGRLKEVYF"

     misc_feature    316..552
                     /gene="SLX5"
                     /locus_tag="YDL013W"
                     /gene_synonym="HEX3; ULS2"
                     /note="Bacterial protein of unknown function (DUF916);
                     Region: DUF916; pfam06030"
                     /db_xref="CDD:428729"
ORIGIN      

atgcatagcgatactaacggtcgaacaaagagcaataatagcccatcagacaataatccaaatgagacagttatattaatagatagtgataaggaagaagacgcttctattcgcgaggctaaccttcctgtgaggttgtacccagacagacgggtagggagacgacgtgatgctttaaataggtttgtgaggtcagattcaaggagcaggaattctcaacggactcacataacagcaagctctgagcgccctgattttcaagctaataacgacgatatcactataatacgagaagttggacggttttttggagacgatggacctattgatccttctgcacattacgtcgatcttgatcaggagccaggttctgaaacgttagaaactccaagaacaatacaagtagataacacaaacgggtacttgaatgataatggtaataacaatgaaagtgatgatggcctgacaatagttgaagagagaacaacacgacccagagtgacactgaacctgccaggcggggagaggcttgaggtaactgcgacgacaacagacataccgataagaaggtcatttgaattccaagaagatctaggcgcatcacgcaggcagttactgagaaggagtgctacaagagcccgtaatttatttgtggaccggtctgatgaaaacgatgaagattggacagatgatacccataatttaccagaagctattcaaagggctcgtagggagagccgtatgcgaatgagcagacggattgcagaaagacaacgtagggtacaacagcaaagggtgtccagtgacgaaaatataagtacatctattaggttacaatcaatcagggaacgaatacaatcatatacgcctgatattcgtagtgcttttcatcgtgcagagtcactgcatgaattcaggtctattttacaaaatgttgctccaattactttgcaagaatgtgaagaagaactaatggcactcttcactgagttcagaaatcaactgctgcagaattgggccattgatagggtcagaaatactcaggaagaggccttgagacttcaccgagaagcattggaaagacaagaaagaacggcaggaagagttttccatcgtggcacattacgtgaatcaatcacaaactatcttaatttcaatggagaggatgggttcttaagtcgtttgtggagtggcccagcattgagcgatgctgacgaggaacgacacactcaaaatatcattgatatgatccaagagagagaagaacgagagcgggatgtggtcatgaagaatctaatgaacaaaaccagagcccaacaggaagaattcgaagctagggcagccagcctacccgaaggttatagcgcgtcatttgatactacgccaaaaatgaaattagacattacgaaaaatggtaaagaagaaaccatcattgtgacagatgacgatttagcaaaaacactcgaggatattcctgtttgttgcttgtgtggcgcagaattgggggtcggaataccggatgattttactggaatcagtcaaaaggatcgtggtgtttcatttgaagggttagtgtcaaaatacaaattccactgcccctaccaaaccctagccagaccatcaatgcttgatagagatttatcaaaacgaacgtttattgcatcgtgtggtcatgcattttgtggtaggtgtttcgccaggattgacaatgcaaaaaaaaaatctaagatgcccaaaaagaaactagctcaactaaagggttcggctcatccggataattatggccccaaattatgtcccgcagattcttgtaagaagcttattcgttcaagaggcaggttgaaggaggtttacttctag

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