LOCUS       NM_001108363            1522 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus H6 family homeobox 1 (Hmx1), mRNA.
ACCESSION   NM_001108363 XM_001064149 XM_341238
VERSION     NM_001108363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Quina,L.A., Kuramoto,T., Luquetti,D.V., Cox,T.C., Serikawa,T. and
            Turner,E.E.
  TITLE     Deletion of a conserved regulatory element required for Hmx1
            expression in craniofacial mesenchyme in the dumbo rat: a newly
            identified cause of congenital ear malformation
  JOURNAL   Dis Model Mech 5 (6), 812-822 (2012)
   PUBMED   22736458
  REMARK    GeneRIF: Dysregulation of Hmx1 expression is a candidate mechanism
            for congenital ear malformation.
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Amendt,B.A., Sutherland,L.B. and Russo,A.F.
  TITLE     Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared
            DNA-binding site
  JOURNAL   J Biol Chem 274 (17), 11635-11642 (1999)
   PUBMED   10206974
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Yoshiura,K., Leysens,N.J., Reiter,R.S. and Murray,J.C.
  TITLE     Cloning, characterization, and mapping of the mouse homeobox gene
            Hmx1
  JOURNAL   Genomics 50 (1), 61-68 (1998)
   PUBMED   9628823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001108363.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577861.1, SRR22582416.1423171.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000014.1  79589248-79589626   c
            380-1522            JAXUCZ010000014.1  79585840-79586982   c
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1522
                     /gene="Hmx1"
                     /note="H6 family homeobox 1"
                     /db_xref="GeneID:360960"
                     /db_xref="RGD:1304928"
     exon            1..379
                     /gene="Hmx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1005
                     /gene="Hmx1"
                     /note="H6 homeo box 1"
                     /codon_start=1
                     /product="homeobox protein HMX1"
                     /protein_id="NP_001101833.2"
                     /db_xref="GeneID:360960"
                     /db_xref="RGD:1304928"
                     /translation="

MPDELTEPGRATPARASSFLIENLLAAEAKGSGRAAQGDGVREEEEEDDDDPEDEDPEQARRRRLQRRRQQRAGSGPGGEARARALGLGPRPPPGPGPPFALGCGGATRWYPRAQGGYGGGLSPDTSDRDSPETGEDMGRAESAWPRCPGPGAVPREVTTQGPAAGGEEAAELAEAPAVAAAAAGEARGGRRKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASLSPPGAQRLVRVPVLYHESPPAATGPTLPFPLAPPAPAPPPPLLGFSGALAYPLAAFPAAASVPFLRAQMPGLV"

     misc_feature    580..750
                     /gene="Hmx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            380..1522
                     /gene="Hmx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcgatgccggatgagctgaccgagcccgggcgtgccacgccggctcgcgcctcctccttcctcatagagaacctgctggcagccgaggccaagggctcggggcgcgcagcccagggcgatggcgtccgcgaggaagaggaggaagacgacgacgaccctgaggacgaggatccggagcaggcccgacgacgacgactacagcggcggcgacagcagcgcgcaggcagcgggccgggcggagaggcgagggcccgagcgctgggcctagggccccggccgcctcccgggcccgggccgcccttcgctctcggctgcggaggcgcgacgcggtggtacccacgggcgcagggcggctacggaggtggtctgagtcctgacacaagcgaccgggactctccggagaccggcgaggatatgggccgcgcagagagcgcctggccgcggtgcccggggccgggagccgttccgcgggaggtgacgacgcagggcccggctgccggcggggaggaagcggcggagttggccgaggctccggcggtggcagccgctgcggcaggggaggcacgcggcggtcgcaggaagaagacgcgcacggtcttctcgcgcagccaggtcttccagctcgagtccactttcgatctgaaacgctacctgagcagcgcggagcgcgcaggcctcgccgcctcgctgcaactcacggagacgcaggtcaagatctggtttcagaaccgccgcaacaagtggaagcggcagctggcggccgagctggaggcggctagcctgtccccgcccggcgcgcagcgcctggtccgcgtgccggtgctctaccacgagagtcccccggccgccacggggcccacgctgcccttcccgctggctccgcctgcacccgcgccgccgccgccgctgctcggtttctcgggcgcgcttgcctacccgctggccgccttccccgccgccgcctcggtgcccttccttcgcgcgcagatgccggggctagtgtgagccggcgccctccatgcaggggcgccgggaggaggcggtgagaggaaggcgccatgcgcctcacgcagttcctcgggcgaccgtctccgtgggcagctgctccagagtgtacccagtgtaccgagtgtactgagtgtaccggacggcggcagcggggactctcagctagctgcaggactgaagacccgttccaatagaaagcggtggccggcaccgagtgctgagcagctgcgggctccgcagcagcaaacggacacttggagtgggctggccaagggaccgcatggcgactatccctgaggcaatcttgcccctaactcagaatgtccttttctcaggagggacctcgcaggaacccttccaagggacaatacagagagccgcggggggccttgggacaactgatcttgggtttcactcttgggtggccttggttctcttggcttgatgaagacttttttttttctgtgatgaatctacttctttgcatatggaataaaaagggacgttttctgga

//