LOCUS       NM_001106302            1362 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus H6 family homeobox 3 (Hmx3), mRNA.
ACCESSION   NM_001106302 XM_001054019 XM_219327
VERSION     NM_001106302.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Wang W, Grimmer JF, Van De Water TR and Lufkin T.
  TITLE     Hmx2 and Hmx3 homeobox genes direct development of the murine inner
            ear and hypothalamus and can be functionally replaced by Drosophila
            Hmx
  JOURNAL   Dev Cell 7 (3), 439-453 (2004)
   PUBMED   15363417
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H,
            Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura
            Y and Kawakami K.
  TITLE     Six1 controls patterning of the mouse otic vesicle
  JOURNAL   Development 131 (3), 551-562 (2004)
   PUBMED   14695375
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Amendt BA, Sutherland LB and Russo AF.
  TITLE     Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared
            DNA-binding site
  JOURNAL   J Biol Chem 274 (17), 11635-11642 (1999)
   PUBMED   10206974
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Wang W, Van De Water T and Lufkin T.
  TITLE     Inner ear and maternal reproductive defects in mice lacking the
            Hmx3 homeobox gene
  JOURNAL   Development 125 (4), 621-634 (1998)
   PUBMED   9435283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219327.4, XM_001054019.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1362
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /note="H6 family homeobox 3"
                     /db_xref="GeneID:293537"
                     /db_xref="RGD:1559927"
     CDS             1..1071
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /note="H6 homeo box 3"
                     /codon_start=1
                     /product="homeobox protein HMX3"
                     /protein_id="NP_001099772.1"
                     /db_xref="GeneID:293537"
                     /db_xref="RGD:1559927"
                     /translation="

MPEPGPDASGTASAPPPQPPPQPPAPKESPFSIRNLLNGDHHRPPPKPQPPPRTLFAPASAAAAAAAAAAAAAKGALEGAAGFALSQVGDLAFPRFEIPAQRFALPAHYLERSPAWWYPYTLTPAGGHLPRPEASEKALLRDSSPASGTDRDSPDPLLKADPDHKELDSKSPDEIILEESDSEEGKKEGEAVPGAAGTTVGATAATPGSEDWKAGADSPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGAAAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRPV"

     misc_feature    order(682..696,700..702,751..753,769..771,808..810,
                     814..819,826..831,835..843,847..852)
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    688..849
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(688..690,697..699,817..819,826..831,838..840)
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            1..400
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /inference="alignment:Splign:2.1.0"
     exon            401..1362
                     /gene="Hmx3"
                     /gene_synonym="RGD1559927"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgccggagcccgggccggacgcctcgggcactgccagcgcgccgcccccgcagcctcctccccagcctcccgcgcccaaggaatccccgttctccatcaggaacctgctcaacggagaccatcaccggccgcccccgaagccacagccgcccccacgaacgctctttgcgccggcctcggccgccgccgctgcggccgccgctgccgccgccgcagccaaaggtgccctggagggtgccgcgggcttcgcgctctcgcaggtgggagacctggccttcccccgctttgagatcccagcgcagaggtttgcattgcccgcgcactacctggagcgctccccggcctggtggtacccctacaccctgacccccgccggcggccacctcccgcgaccagaagcctctgagaaggccctcctgcgcgattcctcccctgcgtccggcacagaccgcgactccccggaccctctgctcaaggctgaccccgaccacaaggagctggactccaagagcccggacgagatcattctggaagagagcgactcggaggaaggcaaaaaagaaggcgaggcggtgcctggcgcggccgggacgacagtaggggcgactgcggcgacaccgggctcagaggactggaaggcgggcgccgacagtcccgagaagaagccggcgtgccgcaaaaagaagacgcgcaccgtcttctcccgcagccaggtcttccagctcgagtccaccttcgacatgaagcgctacctgagcagctcggagcgcgccggcctggccgcgtcgcttcacctcaccgagacgcaggtcaagatctggttccagaatcgccgcaacaagtggaagcgacagctggcggccgagctggaggcggccaacctgagccacgccgctgcgcagcgcatcgtgcgcgtgcccatcctctaccacgagaactctgcggccgagggggcggcggcggccgcaggggccccggtgccggtcagccagccgctgctcaccttcccgcaccctgtctactactcgcacccggtggtctcgtctgtgccgctgctacggccggtgtgagacgggagaggggagagggaatgagcacccggccacctttcggggatcccggaggagactgggccgggccgagggtgccgggctgtggccagcgaccttgggctcactgccttgcctcccaccccccaatagcattttgtaagtatttgcaatgcattttcgtgcaattcattcctatgaatttgaggcgcttctcctcttatttttggttttgctttccattaagagaaaacgaggtggggttgggagggaacgacaaaataaccaggtcaaaacttccaattgaaagtt

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