LOCUS       NM_001100174            2861 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aristaless related homeobox (Arx), mRNA.
ACCESSION   NM_001100174 XM_001064618 XM_228590
VERSION     NM_001100174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Navik,U., Rawat,K. and Tikoo,K.
  TITLE     L-Methionine prevents beta-cell damage by modulating the expression
            of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
  JOURNAL   Acta Histochem 124 (1), 151820 (2022)
   PUBMED   34871948
  REMARK    GeneRIF: L-Methionine prevents beta-cell damage by modulating the
            expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic
            rats.
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Curie,A., Nazir,T., Brun,A., Paulignan,Y., Reboul,A., Delange,K.,
            Cheylus,A., Bertrand,S., Rochefort,F., Bussy,G., Marignier,S.,
            Lacombe,D., Chiron,C., Cossee,M., Leheup,B., Philippe,C.,
            Laugel,V., De Saint Martin,A., Sacco,S., Poirier,K., Bienvenu,T.,
            Souville,I., Gilbert-Dussardier,B., Bieth,E., Kauffmann,D.,
            Briot,P., de Freminville,B., Prieur,F., Till,M., Rooryck-Thambo,C.,
            Mortemousque,I., Bobillier-Chaumont,I., Toutain,A., Touraine,R.,
            Sanlaville,D., Chelly,J., Freeman,S., Kong,J., Hadjikhani,N.,
            Gollub,R.L., Roy,A. and des Portes,V.
  TITLE     The c.429_452 duplication of the ARX gene: a unique
            developmental-model of limb kinetic apraxia
  JOURNAL   Orphanet J Rare Dis 9, 25 (2014)
   PUBMED   24528893
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Poeta,L., Fusco,F., Drongitis,D., Shoubridge,C., Manganelli,G.,
            Filosa,S., Paciolla,M., Courtney,M., Collombat,P., Lioi,M.B.,
            Gecz,J., Ursini,M.V. and Miano,M.G.
  TITLE     A regulatory path associated with X-linked intellectual disability
            and epilepsy links KDM5C to the polyalanine expansions in ARX
  JOURNAL   Am J Hum Genet 92 (1), 114-125 (2013)
   PUBMED   23246292
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Du,A., McCracken,K.W., Walp,E.R., Terry,N.A., Klein,T.J., Han,A.,
            Wells,J.M. and May,C.L.
  TITLE     Arx is required for normal enteroendocrine cell development in mice
            and humans
  JOURNAL   Dev Biol 365 (1), 175-188 (2012)
   PUBMED   22387004
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Yoshihara,S., Omichi,K., Yanazawa,M., Kitamura,K. and Yoshihara,Y.
  TITLE     Arx homeobox gene is essential for development of mouse olfactory
            system
  JOURNAL   Development 132 (4), 751-762 (2005)
   PUBMED   15677725
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Poirier,K., Van Esch,H., Friocourt,G., Saillour,Y., Bahi,N.,
            Backer,S., Souil,E., Castelnau-Ptakhine,L., Beldjord,C.,
            Francis,F., Bienvenu,T. and Chelly,J.
  TITLE     Neuroanatomical distribution of ARX in brain and its localisation
            in GABAergic neurons
  JOURNAL   Brain Res Mol Brain Res 122 (1), 35-46 (2004)
   PUBMED   14992814
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Kitamura,K., Yanazawa,M., Sugiyama,N., Miura,H., Iizuka-Kogo,A.,
            Kusaka,M., Omichi,K., Suzuki,R., Kato-Fukui,Y., Kamiirisa,K.,
            Matsuo,M., Kamijo,S., Kasahara,M., Yoshioka,H., Ogata,T.,
            Fukuda,T., Kondo,I., Kato,M., Dobyns,W.B., Yokoyama,M. and
            Morohashi,K.
  TITLE     Mutation of ARX causes abnormal development of forebrain and testes
            in mice and X-linked lissencephaly with abnormal genitalia in
            humans
  JOURNAL   Nat Genet 32 (3), 359-369 (2002)
   PUBMED   12379852
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Scheffer,I.E., Wallace,R.H., Phillips,F.L., Hewson,P., Reardon,K.,
            Parasivam,G., Stromme,P., Berkovic,S.F., Gecz,J. and Mulley,J.C.
  TITLE     X-linked myoclonic epilepsy with spasticity and intellectual
            disability: mutation in the homeobox gene ARX
  JOURNAL   Neurology 59 (3), 348-356 (2002)
   PUBMED   12177367
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Bienvenu,T., Poirier,K., Friocourt,G., Bahi,N., Beaumont,D.,
            Fauchereau,F., Ben Jeema,L., Zemni,R., Vinet,M.C., Francis,F.,
            Couvert,P., Gomot,M., Moraine,C., van Bokhoven,H., Kalscheuer,V.,
            Frints,S., Gecz,J., Ohzaki,K., Chaabouni,H., Fryns,J.P.,
            Desportes,V., Beldjord,C. and Chelly,J.
  TITLE     ARX, a novel Prd-class-homeobox gene highly expressed in the
            telencephalon, is mutated in X-linked mental retardation
  JOURNAL   Hum Mol Genet 11 (8), 981-991 (2002)
   PUBMED   11971879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF638804.1.
            
            On or before Jul 29, 2007 this sequence version replaced
            XM_228590.4, XM_001064618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF638804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2861
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="aristaless related homeobox"
                     /db_xref="GeneID:317268"
                     /db_xref="RGD:1562672"
     exon            1..392
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2..4
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="upstream in-frame stop codon"
     CDS             197..1897
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /codon_start=1
                     /product="homeobox protein ARX"
                     /protein_id="NP_001093644.1"
                     /db_xref="GeneID:317268"
                     /db_xref="RGD:1562672"
                     /translation="

MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRTDQEKAMQGSPKGSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVAHPEERLSAASGPGSAPAAGGGTGTEEDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC"

     misc_feature    197..259
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="propagated from UniProtKB/Swiss-Prot (A6YP92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    344..433
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="propagated from UniProtKB/Swiss-Prot (A6YP92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    551..988
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="propagated from UniProtKB/Swiss-Prot (A6YP92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1052..1153
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="propagated from UniProtKB/Swiss-Prot (A6YP92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1193..1363
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1784..1840
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     misc_feature    1796..1837
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /note="propagated from UniProtKB/Swiss-Prot (A6YP92.1);
                     Region: OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
     exon            393..1281
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1327
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1656
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..2851
                     /gene="Arx"
                     /gene_synonym="RGD1562672"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctgagcgcggagaggacgagctccggctgaggtcagagtgggagcccgcatccgaggggggcagaaaggaacaaagatcgcagtaatacctgttataatcagcaatctaacccatccccaacacacactctttcaccctaccggccaggagaggcaggcagaggtccactctgagcccaaggaaaaagctccaaccatgagcaatcagtaccaggaagagggctgctctgagaggcccgagtgcaagagtaaatcgccaactttgctctcctcctactgcatcgacagcatcctgggccggagaagcccgtgcaaaatgaggcttctgggagccgcgcagagcttgcctgccccgctggccagccgtactgaccaagaaaaagccatgcaaggctcccccaagggcagcagcgccccgttcgaggctgagctgcacctgccacccaagctgcggcgcctgtacggcccgggcgggggccgcctcctccagggcgcagcagcggcggcagcggcggcggccgcggcggcggcggcggcagccacggccactggcaccgcaggtccccgtggagaggttcctccaccgccaccgccagcagcacggccaggggagcgtcaggacagcgcgggggccgtggccgccgccgccgccgctgcctgggacacgctcaaaattagccaggcaccgcaggtgagcatcagccgcagcaagtcgtaccgcgagaacggggcgcccttcgtgccaccgccgcccgccctggacgagctgggtggtccggggggcgtcgcgcacccagaggagcgcctcagcgcggccagcggacccggcagtgccccggcggcgggtggtggcacgggcaccgaggaggacgaggaggagctgttggaggatgaggaagatgaagatgaggaagaggagctgctggaggacgacgaggaggagctgctggaagacgatgcccgcgcgctactcaaggagccccggcgctgctctgtggccaccactggcacggtggccgccgccgccgccgccgccgctgccgccgccgccgtggccaccgagggcggggagctgtcgcccaaggaagagctgttgctgcacccggaggacgccgagggcaaggatggtgaggacagcgtgtgcctgtccgccggcagcgactccgaggaggggctcctgaagcgcaaacagaggcgttaccgcaccacgttcaccagttaccagctggaggaactggagcgggctttccagaagacacactaccctgacgtcttcaccagggaggagctggccatgaggctggacctgactgaggcccgagtccaggtgtggttccagaaccgcagggccaagtggcgcaagcgggagaaggctggcgcgcagacccaccccccggggctgccctttcccgggccactctcggctacccaccctctcagcccctacctggacgccagcccctttcccccgcatcacccagcgcttgactcggcctggaccgccgccgctgcagcggctgcagctgccttcccgagcctacctccgcccccgggctctgctagcctgccgcccagcggggcgccgctgggcctgagcactttcctgggagcagccgtgttccggcacccggccttcatcagcccagcatttggcaggctcttttccactatggcccccctgaccagcgcgtcgaccgcggctgcgctcctgagacagcccacacccgcagtggagggcgcagtggcctcgggcgcgctggccgatcccgccaccgctgcggcagacagacgcgcatcgagcatagcggcgctgaggctcaaggctaaggagcacgccgcgcagctcacgcagctcaacatcctcccgggcaccagcacggggaaggaggtgtgctaaaggctgccctccgcccttgcgcccctagggcgcgccccgaaaggtcacctcactcagcaccactcaagaccaaatggaaacagaggaccagctcactcccaagacggcaaagacagagcgcagccgccttcgcagcagcctggaccctggacgcggacaaggcagctcttggcgctaaaggacgtggcacctcttccgttggctgtccatttgcccttgtccctgtccctacccctgccactgccaacgtcactccaactcaaatgtccacgctcccgtttttatcttactgaaaacaagcgggagggtttctccccaatatgcctagtattgaagttttaaaaattaaaagcccaaccttctcttcctccggataccccacttagcttttcttttgaatagcattttggcgctctaagttgatttaagcgcggcccggctagacagacaccagggccagggaagcgaatacgaatctgtaagatagctaacagtgcacttaaaggaaaggggcgtctcgttcttgttctcttctttatcatacaccaaccaaggtttttatatcaaaccaaagggaaatactctgctagaatatggactgttgaagtcaccaaactgtgattattgattctgtacataccattgttattaaaaaaaaaagaacagagctttgtatatttgaaatgttataacgcaattgcactcagcgtggtatggtaaaagtttgtcctcctgtagattcttactgtgttgtagatatggtagggttcctagacaaatatttatgtactcaagccctttatttaacttattaactgtagaggcttcggaaaccttcaagataaaggcaatggtacagtacttttgtgtaatgtgtaattgttatcacttttccttgctatctagtggagaagtgtcacgctcaaaataaaaaaaaatatatgtttaacaaaaaaaaaaaaaa

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