LOCUS       NM_001033894            2410 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            1 (Jakmip1), transcript variant 6, mRNA.
ACCESSION   NM_001033894 XM_223515
VERSION     NM_001033894.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2410)
  AUTHORS   Berg,J.M., Lee,C., Chen,L., Galvan,L., Cepeda,C., Chen,J.Y.,
            Penagarikano,O., Stein,J.L., Li,A., Oguro-Ando,A., Miller,J.A.,
            Vashisht,A.A., Starks,M.E., Kite,E.P., Tam,E., Gdalyahu,A.,
            Al-Sharif,N.B., Burkett,Z.D., White,S.A., Fears,S.C., Levine,M.S.,
            Wohlschlegel,J.A. and Geschwind,D.H.
  TITLE     JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates
            Synaptic Function and Autistic-like Behaviors in Mouse
  JOURNAL   Neuron 88 (6), 1173-1191 (2015)
   PUBMED   26627310
REFERENCE   2  (bases 1 to 2410)
  AUTHORS   Vidal,R.L., Fuentes,P., Valenzuela,J.I., Alvarado-Diaz,C.P.,
            Ramirez,O.A., Kukuljan,M. and Couve,A.
  TITLE     RNA interference of Marlin-1/Jakmip1 results in abnormal
            morphogenesis and migration of cortical pyramidal neurons
  JOURNAL   Mol Cell Neurosci 51 (1-2), 1-11 (2012)
   PUBMED   22828129
  REMARK    GeneRIF: RNA interference of Marlin-1 in vivo results in abnormal
            migration and abnormal morphology of newborn pyramidal neurons
            during the formation of the cortex.
REFERENCE   3  (bases 1 to 2410)
  AUTHORS   Vidal,R.L., Valenzuela,J.I., Lujan,R. and Couve,A.
  TITLE     Cellular and subcellular localization of Marlin-1 in the brain
  JOURNAL   BMC Neurosci 10, 37 (2009)
   PUBMED   19386132
  REMARK    GeneRIF: Marlin-1 is enriched in restricted areas of the brain
            including olfactory bulb, cerebral cortex, hippocampus and
            cerebellum; it is abundant in dendrites and axons of hippocampal
            neurons, associated with microtubules at the ultrastructural level.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2410)
  AUTHORS   Vidal,R.L., Ramirez,A., Castro,M., Concha,I.I. and Couve,A.
  TITLE     Marlin-1 is expressed in testis and associates to the cytoskeleton
            and GABAB receptors
  JOURNAL   J Cell Biochem 103 (3), 886-895 (2008)
   PUBMED   17668444
  REMARK    GeneRIF: Our findings demonstrate that Marlin-1 associates with a
            microtubule fraction and with GABA(B) receptors in testis
            suggesting that the set of protein interactions of Marlin-1 are
            conserved in different tissues.
REFERENCE   5  (bases 1 to 2410)
  AUTHORS   Nishimura,Y., Martin,C.L., Vazquez-Lopez,A., Spence,S.J.,
            Alvarez-Retuerto,A.I., Sigman,M., Steindler,C., Pellegrini,S.,
            Schanen,N.C., Warren,S.T. and Geschwind,D.H.
  TITLE     Genome-wide expression profiling of lymphoblastoid cell lines
            distinguishes different forms of autism and reveals shared pathways
  JOURNAL   Hum Mol Genet 16 (14), 1682-1698 (2007)
   PUBMED   17519220
REFERENCE   6  (bases 1 to 2410)
  AUTHORS   Vidal,R.L., Ramirez,O.A., Sandoval,L., Koenig-Robert,R., Hartel,S.
            and Couve,A.
  TITLE     Marlin-1 and conventional kinesin link GABAB receptors to the
            cytoskeleton and regulate receptor transport
  JOURNAL   Mol Cell Neurosci 35 (3), 501-512 (2007)
   PUBMED   17532644
REFERENCE   7  (bases 1 to 2410)
  AUTHORS   Couve,A., Restituito,S., Brandon,J.M., Charles,K.J., Bawagan,H.,
            Freeman,K.B., Pangalos,M.N., Calver,A.R. and Moss,S.J.
  TITLE     Marlin-1, a novel RNA-binding protein associates with GABA
            receptors
  JOURNAL   J Biol Chem 279 (14), 13934-13943 (2004)
   PUBMED   14718537
  REMARK    GeneRIF: Marlin-1 functions to regulate the cellular levels of
            GABA(B) R2 subunits, which may have significant effects on the
            production of functional GABA(B) receptor heterodimers.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104677.1.
            
            On Sep 30, 2005 this sequence version replaced XM_223515.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104677.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2410
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="janus kinase and microtubule interacting protein 1"
                     /db_xref="GeneID:305434"
                     /db_xref="RGD:1562401"
     exon            1..69
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..332
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="upstream in-frame stop codon"
     CDS             204..2084
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="isoform 5 is encoded by transcript variant 6;
                     multiple alpha helices and RNA-linker protein 1; multiple
                     coiled-coil GABABR1-binding protein"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     1 isoform 5"
                     /protein_id="NP_001029066.1"
                     /db_xref="GeneID:305434"
                     /db_xref="RGD:1562401"
                     /translation="

MSKKGRSKGEKPETETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQAGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFV"

     misc_feature    204..1298
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1);
                     Region: Mediates association with microtubules.
                     /evidence=ECO:0000250"
     misc_feature    204..278
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <273..>2024
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    1296..2081
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1);
                     Region: Mediates interaction with TYK2 and GABBR1.
                     /evidence=ECO:0000250"
     misc_feature    1347..1349
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96N16; propagated from
                     UniProtKB/Swiss-Prot (Q3SWS9.1); phosphorylation site"
     misc_feature    1446..2018
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1557..1646
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWS9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1611..1613
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96N16; propagated from
                     UniProtKB/Swiss-Prot (Q3SWS9.1); phosphorylation site"
     exon            333..827
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1037
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1157
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1304
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1445
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1505
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1634
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1763
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1847
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1910
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2319
                     /gene="Jakmip1"
                     /gene_synonym="Marlin-1; Marlin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cagccatcctgcagggcagatggagggactcccagacgaggctggaattggttcggggaggtggtagagactctccagtgatggtgtgcacagaggacgagcggaggcctgcacgactgcttagcacagctgagctggtagctgtgcttgccggtgggcaggcgtgaacctcaggacctcagcgtctcactccaagaggaaacatgtctaaaaagggccgcagcaagggtgagaagcccgagacagagacagactctgtacagatggccaatgaagagctacgggccaagctgacgaacatccagatcgagttccagcaggagaagagcaaggtggggaagctgcgggagcgtctgcaggaggccaagctggaacgggagcaggagcagcgtcgccacacggcctacatctcagaactcaaggccaagctgcacgaagagaagacgaaggaactgcaggcgctgcgcgaggcgctcatccggcagcacgagcaggaggcagcgcggaccgccaagatcaaggaaggcgagctgcagcgactgcaggccacgctgaatgtgctgcgcgatggcgccgcggacaaagtcaagactgcattgctggccgacgcgcgcgaggaggcgcgcaggacctttgatggcgagcgccagaggctgcagcaggagattctggaactgaaggctgcgcgcaaacaggcagaagaggcactcagcaactgcatgcaggcagacaaggccaaagccgcggacctgcgcgctgcgtaccaggcgcaccaggatgaggtgcaccgcatcaagcgggagtgtgaacgtgacatccgcagactgatggacgagatcaaaggaaaggaacgcgtgatcctggccctggagaaggagcttggtgtgcaggccgggcagacccagcggctgctattacagaaggaggctctggatgagcagctggtccaggtcaaggaggccgaacgccaccacagcagcccaaagagggagcttcctccaggcattggtgacatggctgagcttatgggtggccaggatcagcatatggacgagcgagatgtgaggcgatttcagctgaagattgccgaactgaattcagtgattcggaagctggaggacaggaacaccctgctggctgatgagaggaacgaactgctgaagcgctctcgggagacggaggtgcagctgaagccgctggtggagaagaacaaacgcatgaataaaaagaacgaggatctgctgcacagcatccaaaggatggaggagaaactcaagagcctcacgagggaaaacgtggagatgaaagaaaagctgtctgcccaggcctcactaaagcgacacacatccctgaatgacctcagtctgaccagggacgagcaggagatagagttcctgaggctgcaggtgctggaacagcagcatgtcattgatgacctctctctggaaagagaacgcctgctgcgctccaagaggcatcgagggaagagcctgaaaccccccaagaagcatgttgtggagacattttttggatttgatgaggagtctgtggactctgaaacattgtcagagacgtcctacaacacagacaggacagaccggaccccagccacgcctgaagaggacttagatgagaccacaaccagagaagaggctgacctgaggttctgccagctgaccagggagtaccaggctctgcagagggcttatgccctgcttcaggagcaggttggggggacgctggatgctgagagggaggctcggactcgggagcaacttcaggctgacctgctgagatgccaggccaaaattgaggacttagagaagctgctggttgagaagggacaggatgctgcgtgggtagaggagaagcaggtactcatgaggacaaaccaggacctgctggagaagatttacaggctggagatggaggagaaccagctaaagagtgaaatgcaagacgccaaggaccagaacgagctgttagaattcagagtgctagaactcgaagtaagagactctatctgttgtaagctctcaaatggagcagacattctctttgagcccaaactgaaattcgtgtaaagctctctgctatttccaagcatgcgtgaagggacgcgcgttaccgtttctctccttccttcctccgttcttttcctcttcgtctttttaaaaagatctgtatgttcggggtaacttcactgccttaacatgtcctggggaggatgctcgcgacgcctgtggacctgtaccagagcaatcgacttattgcctaccgcttgttttgcacttaataaaataagttgtttttgcaataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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