LOCUS       NM_001017736            1461 bp    mRNA    linear   VRT 05-AUG-2023
DEFINITION  Danio rerio claudin 19 (cldn19), mRNA.
ACCESSION   NM_001017736
VERSION     NM_001017736.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1461)
  AUTHORS   Garcia-Concejo A and Larhammar D.
  TITLE     Protein kinase C family evolution in jawed vertebrates
  JOURNAL   Dev Biol 479, 77-90 (2021)
   PUBMED   34329618
REFERENCE   2  (bases 1 to 1461)
  AUTHORS   Tonelli F, Cotti S, Leoni L, Besio R, Gioia R, Marchese L,
            Giorgetti S, Villani S, Gistelinck C, Wagener R, Kobbe B, Fiedler
            IAK, Larionova D, Busse B, Eyre D, Rossi A, Witten PE and Forlino
            A.
  TITLE     Crtap and p3h1 knock out zebrafish support defective collagen
            chaperoning as the cause of their osteogenesis imperfecta phenotype
  JOURNAL   Matrix Biol 90, 40-60 (2020)
   PUBMED   32173581
REFERENCE   3  (bases 1 to 1461)
  AUTHORS   Sun J, Zhou Q and Hu X.
  TITLE     Integrating multi-omics and regular analyses identifies the
            molecular responses of zebrafish brains to graphene oxide:
            Perspectives in environmental criteria
  JOURNAL   Ecotoxicol Environ Saf 180, 269-279 (2019)
   PUBMED   31100591
REFERENCE   4  (bases 1 to 1461)
  AUTHORS   Kossack ME, High SK, Hopton RE, Yan YL, Postlethwait JH and Draper
            BW.
  TITLE     Female Sex Development and Reproductive Duct Formation Depend on
            Wnt4a in Zebrafish
  JOURNAL   Genetics 211 (1), 219-233 (2019)
   PUBMED   30446521
REFERENCE   5  (bases 1 to 1461)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1461)
  AUTHORS   Shu Y, Lou Q, Dai Z, Dai X, He J, Hu W and Yin Z.
  TITLE     The basal function of teleost prolactin as a key regulator on ion
            uptake identified with zebrafish knockout models
  JOURNAL   Sci Rep 6, 18597 (2016)
   PUBMED   26726070
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1461)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1461)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093218.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="11"
                     /map="11"
     gene            1..1461
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /note="claudin 19"
                     /db_xref="GeneID:550431"
                     /db_xref="ZFIN:ZDB-GENE-050417-242"
     exon            1..326
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    65..67
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /note="upstream in-frame stop codon"
     CDS             104..733
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /codon_start=1
                     /product="claudin-19"
                     /protein_id="NP_001017736.1"
                     /db_xref="GeneID:550431"
                     /db_xref="ZFIN:ZDB-GENE-050417-242"
                     /translation="

MANSGFQLLGYFLALGGWIGIISTTVLPQWKQSSYAGDAIIMAVGLYEGLWMSCASQSTGQVQCKIFDSLLSLDVNIQTCRALMVISVLMGFMGIIVSVVGMKCTKVGDNNPSTKSKIAISGGSLFLLSGVCTLVAVSWYAAQVSAHFFDPNTPTNAKYDFGTALFVGWAASVLMMLGGAFLCCSCINEDRRGQQFYRQSQPSTTREYV"

     misc_feature    113..649
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
     exon            327..491
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /inference="alignment:Splign:2.1.0"
     exon            492..576
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /inference="alignment:Splign:2.1.0"
     exon            577..1457
                     /gene="cldn19"
                     /gene_synonym="zgc:112141"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cttttgcacgctgttgagggaatcgcagttgtctggttcctgaccggaggacgtgtttacactctaattgcaaactaaaagaaacactaaagaaagggctactatggccaactctgggtttcagcttctgggctactttctggcattgggaggatggattgggatcatctccactacggtgctaccccagtggaagcagtcctcgtatgcaggggatgccatcatcatggctgtgggcttgtatgagggcctgtggatgtcctgtgcatctcagagtacaggccaggtgcagtgcaagatcttcgactctttgctttcgctggacgtcaacattcagacgtgtcgagctctgatggtgatctctgtgctcatgggcttcatgggtatcattgtaagtgtggtcggcatgaagtgcacaaaggtgggtgacaacaacccatccacaaagagcaagatcgccatctctggtgggagtctattcctgctctcaggtgtctgcacgctggtggccgtgtcctggtatgccgcacaggtgtctgcccacttcttcgaccccaacacaccaactaatgccaagtacgattttggaaccgccctctttgtggggtgggcggcgtccgtcctgatgatgctgggcggcgcgttcctttgctgctcctgcatcaacgaggacagaagaggacagcagttctaccggcaatctcagccctccacaaccagagagtatgtgtaaatacaaacctataactgcactgcagcaaaggacaaactctaactgtaaagagcagcgcatacaagagacagagctctttccaccatgagtacaccttcacactcgcaatgatcgtttatccaggtccaaaacactcaaactaaacccttaccagacaaatacttacattgtcaagacctacggtcacagaggtttgtgtactgctttcagagatactgtacaaatgtgtatttttgctatactttcattttcaagaaaacaatgtggaaattccgtactgattttgacaaatacggttttctcatcaagcattaataagcttttaaatgaaagaaatcctttctataaaccaatttgaagctgaactccctaagttgtaaaaagcattaacactggacatttttatatagttactctaacataggtttcagggaaactttcatgtgttttcatgaaaagtgaattaaaagtattatttgtggacaaagtctaatcaacaggattttttttttgttagctaaaaggcaaataaataataataataaaaaaaagattccacatggagtacagcatctatgtttggactagaaccctactttctcaaattctgcagtatataatatacataatgtgaacgtatgcatgaaatacactgactacccaaacttttttttaaacaagatcaaaagccttttttttgttgccaaaattaaaaaaaaaaaaaaaaa

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