LOCUS       NM_001401067            2297 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ring finger protein 41 (Rnf41), transcript
            variant 1, mRNA.
ACCESSION   NM_001401067 XM_006240774
VERSION     NM_001401067.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent
            Hypoxia in Rats via Regulating the Protein Levels of ErbB3
  JOURNAL   Neurotox Res 38 (1), 124-132 (2020)
   PUBMED   32200526
  REMARK    GeneRIF: Role of the Nrdp1 in Brain Injury Induced by Chronic
            Intermittent Hypoxia in Rats via Regulating the Protein Levels of
            ErbB3.
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Zheng,J., Min,S., Hu,B., Liu,Q. and Wan,Y.
  TITLE     Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary
            bypass-induced cognitive dysfunction via the regulation of ErbB3
            protein levels
  JOURNAL   Int J Mol Med 43 (4), 1747-1757 (2019)
   PUBMED   30720051
  REMARK    GeneRIF: Nrdp1 serves an important role in regulating the apoptosis
            induced by cardiopulmonary bypass in vivo and in vitro through
            regulating ErbB3 and phosphoAKT protein levels.
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Hatakeyama,J., Wald,J.H., Rafidi,H., Cuevas,A., Sweeney,C. and
            Carraway,K.L. 3rd.
  TITLE     The ER structural protein Rtn4A stabilizes and enhances signaling
            through the receptor tyrosine kinase ErbB3
  JOURNAL   Sci Signal 9 (434), ra65 (2016)
   PUBMED   27353365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Zhang,Y., Su,L. and Zhang,K.
  TITLE     Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in
            Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene
            Network Analysis
  JOURNAL   Cardiology 135 (4), 203-215 (2016)
   PUBMED   27428330
  REMARK    GeneRIF: Pathway network analysis identified myocardial metabolism,
            DNA replication, and the cell cycle as the most important pathways
            targeted by Nrdp1.
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Zhang,Y., Zeng,Y., Wang,M., Tian,C., Ma,X., Chen,H., Fang,Q.,
            Jia,L., Du,J. and Li,H.
  TITLE     Cardiac-specific overexpression of E3 ligase Nrdp1 increases
            ischemia and reperfusion-induced cardiac injury
  JOURNAL   Basic Res Cardiol 106 (3), 371-383 (2011)
   PUBMED   21312039
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Jing,X., Infante,J., Nachtman,R.G. and Jurecic,R.
  TITLE     E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic
            progenitors by governing steady-state levels of cytokine and
            retinoic acid receptors
  JOURNAL   Exp Hematol 36 (9), 1110-1120 (2008)
   PUBMED   18495327
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Yu,F. and Zhou,J.
  TITLE     Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced
            oxidative stress
  JOURNAL   Neurosci Lett 440 (1), 4-8 (2008)
   PUBMED   18541373
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Yen,L., Cao,Z., Wu,X., Ingalla,E.R., Baron,C., Young,L.J.,
            Gregg,J.P., Cardiff,R.D., Borowsky,A.D., Sweeney,C. and
            Carraway,K.L. 3rd.
  TITLE     Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell
            growth
  JOURNAL   Cancer Res 66 (23), 11279-11286 (2006)
   PUBMED   17145873
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J 23 (4), 800-810 (2004)
   PUBMED   14765125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006240774.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1252030.1,
                                           SRR26360172.1486622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000007.1  1422754-1422925
            173-355             JAXUCZ010000007.1  1426408-1426590
            356-468             JAXUCZ010000007.1  1438095-1438207
            469-740             JAXUCZ010000007.1  1444473-1444744
            741-876             JAXUCZ010000007.1  1445614-1445749
            877-980             JAXUCZ010000007.1  1446095-1446198
            981-2297            JAXUCZ010000007.1  1446848-1448164
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2297
                     /gene="Rnf41"
                     /note="ring finger protein 41"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
     exon            1..172
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            173..355
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            356..468
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    373..375
                     /gene="Rnf41"
                     /note="upstream in-frame stop codon"
     CDS             379..1332
                     /gene="Rnf41"
                     /EC_number="6.3.2.38"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase NRDP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NRDP1 isoform 1"
                     /protein_id="NP_001387996.1"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
                     /translation="

MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"

     misc_feature    421..549
                     /gene="Rnf41"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in neuregulin receptor degradation protein-1 (Nrdp1)
                     and similar proteins; Region: mRING-HC-C3HC3D_Nrdp1;
                     cd16634"
                     /db_xref="CDD:438296"
     misc_feature    607..>861
                     /gene="Rnf41"
                     /note="Seven in absentia protein family; Region: Sina;
                     pfam03145"
                     /db_xref="CDD:460824"
     misc_feature    787..1323
                     /gene="Rnf41"
                     /note="USP8 interacting; Region: USP8_interact; pfam08941"
                     /db_xref="CDD:430333"
     exon            469..740
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            741..876
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            877..980
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2297
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caagggctagctcgagaaggcgaggagtggtcggaaccttcttctccatccttctcttccccttcccctacggggaaaggttgagacccggtacgcaggctgcgccgcggcccccgtggcctcagctacagccaggtcccgcgtccggagaagccaggccgcgtcccgtgcgagcgctcctgattgtgacatcacacccacccctgggccatgaaacttgtctctaggaagaaagactcagttggagaatagccaacaagatgggatacttggagtgtctcctgagtggcaccaagcagaggcatcaggggcttggaaccttgtgaacagggaacctgcccccaccacttagaaggacctgggtttcagtgatgagacatggggtatgatgtaacccggttccagggggacgttgacgaggacctcatctgccctatttgcagtggagtcttggaggagccagtacaggcgcctcattgtgagcatgccttctgcaacgcctgcatcacccaatggttctctcagcagcagacgtgtccggtagaccgtagcgttgtcacggttgcccacctgcgcccagtgcctcggatcatgcggaacatgttgtcaaagctgcagattgcctgtgacaacgctgtgtttggctgcagtgctgttgtcaggcttgacagcctcatgtcccacctcagtgactgtgagcacaacccgaagcggcctgtgacctgcgagcagggctgcggcctggagatgcccaaagatgagctgccaaaccacaattgcattaagcacctgcgctccgtggtccagcagcagcagacgcgcatcgcagagctggagaagacatctgctgaacacaagcaccagctggcagaacagaagcgagacattcagttgctgaaggcgtatatgcgagccatccgcagtgtcaaccccaaccttcagaacctggaggagacaatcgagtacaacgagatccttgagtgggtgaactccctacagccggcaagagtgacgcgctggggggggatgatctccactcctgacgctgtgctgcaggctgtaatcaagcgctccctcgtggaaagtggctgcccagcttctatcgtcaacgagctgatcgaaaatgcccatgaacgcagctggccccagggtctggccacactagagacaagacagatgaaccggcgctactatgagaactacgtggccaagcgcatccctggcaagcaggctgtggtggtgatggcctgcgagaaccagcacatgggtgacgacatggtgcaggagccggggctggtcatgatctttgcacatggtgtggaggagatttaagagcgtgactgactatgaggaagaggtagagtgggaacctatggccgctccagcagctgagccctgacctccccacacacaaccctgtgccacggcttgtactggagcctcgcactccctgcttctggcatgaaggaccttgggccacttagctcagcctttcagcggggaacccaagttcctgccttttgctatattcctccccccacaatgtctgtaaattttcagtcagggtggagaaatccccacttctgtatttgctgactaagatccctggttcccaaatattttcagaaagcacaaagacacttgttttccctagagggtcagggtggagtgaggcatttctacacttgatcttagccaaaaggccgagaagcgatgagtgaggcatttctaattgtccctctcttccaaaaccaggggatccaagcaggcaggcttgctggctccatgcagcattgagagagcagctctgacatccagcagaagggctaacagtgtgaccaaagcccctctaactagtgaggccaggacttggtcctcactaacagcccttggggaagacctttgtgctgagcacatccctgtccaggcccctgtgactgtgcaggccttgctgggtgtgcagggaaggaagagggtaggcattggtgttcacgcactcagcaggaaagctgtctggctctgctgaaggaggataccactgccccttgaggcacgtctatgttgcctcgtaggcccctcttcagtcctgtgattgtagttggctggatttcctttggtgtttgtttatattccccaagtctcaaacctcatctgttacccagtcttgttttcatagaatggactggctgtgtctgtcctccgatccagcccagccacattgttggcaatttaatttatttacttttttttttttaagaaaggagaaaagaaaaaaaaatgaagaaaacttaaaacct

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