2024-05-17 01:44:12, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_008770 1872 bp mRNA linear ROD 12-SEP-2023 DEFINITION Mus musculus claudin 11 (Cldn11), mRNA. ACCESSION NM_008770 VERSION NM_008770.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1872) AUTHORS Maezawa S, Yukawa M, Hasegawa K, Sugiyama R, Iizuka M, Hu M, Sakashita A, Vidal M, Koseki H, Barski A, DeFalco T and Namekawa SH. TITLE PRC1 suppresses a female gene regulatory network to ensure testicular differentiation JOURNAL Cell Death Dis 14 (8), 501 (2023) PUBMED 37542070 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1872) AUTHORS Jiang X, Cheng Y, Zhu Y, Xu C, Li Q, Xing X, Li W, Zou J, Meng L, Azhar M, Cao Y, Tong X, Qin W, Zhu X and Bao J. TITLE Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice JOURNAL Nat Commun 14 (1), 3729 (2023) PUBMED 37349316 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1872) AUTHORS Derk J, Como CN, Jones HE, Joyce LR, Kim S, Spencer BL, Bonney S, O'Rourke R, Pawlikowski B, Doran KS and Siegenthaler JA. TITLE Formation and function of the meningeal arachnoid barrier around the developing mouse brain JOURNAL Dev Cell 58 (8), 635-644 (2023) PUBMED 36996816 REFERENCE 4 (bases 1 to 1872) AUTHORS Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH, Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH, Lovell-Badge R and Cheah KSE. TITLE SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms JOURNAL Proc Natl Acad Sci U S A 119 (46), e2122121119 (2022) PUBMED 36343245 REFERENCE 5 (bases 1 to 1872) AUTHORS Drake KA, Chaney C, Patel M, Das A, Bittencourt J, Cohn M and Carroll TJ. TITLE Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney JOURNAL J Am Soc Nephrol 33 (9), 1694-1707 (2022) PUBMED 35918150 REMARK Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. PMID: 36857501] REFERENCE 6 (bases 1 to 1872) AUTHORS Morita K, Sasaki H, Fujimoto K, Furuse M and Tsukita S. TITLE Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis JOURNAL J Cell Biol 145 (3), 579-588 (1999) PUBMED 10225958 REFERENCE 7 (bases 1 to 1872) AUTHORS Rajan L, Kozak CA and Dudley JP. TITLE Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas JOURNAL Mamm Genome 9 (1), 84-85 (1998) PUBMED 9434954 REFERENCE 8 (bases 1 to 1872) AUTHORS Gay D, Lavi E, Zhao H, Mumin A and Bhandoola A. TITLE OlP-1, a novel protein that distinguishes early oligodendrocyte precursors JOURNAL J Neurosci Res 50 (4), 591-604 (1997) PUBMED 9404721 REFERENCE 9 (bases 1 to 1872) AUTHORS Bronstein JM, Popper P, Micevych PE and Farber DB. TITLE Isolation and characterization of a novel oligodendrocyte-specific protein JOURNAL Neurology 47 (3), 772-778 (1996) PUBMED 8797478 REFERENCE 10 (bases 1 to 1872) AUTHORS Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR and Farber DB. TITLE Chromosomal localization of murine and human oligodendrocyte-specific protein genes JOURNAL Genomics 34 (2), 255-257 (1996) PUBMED 8661061 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY110541.1, AK005088.1 and BB798247.1. On Aug 10, 2010 this sequence version replaced NM_008770.2. Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005088.1, AK161698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-26 BY110541.1 2-27 27-1540 AK005088.1 2-1515 1541-1872 BB798247.1 66-397 FEATURES Location/Qualifiers source 1..1872 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="3" /map="3 15.14 cM" gene 1..1872 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="claudin 11" /db_xref="GeneID:18417" /db_xref="MGI:MGI:106925" exon 1..456 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /inference="alignment:Splign:2.1.0" misc_feature 153..155 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="upstream in-frame stop codon" CDS 231..854 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="oligodendrocyte transmembrane protein; oligodendrocyte-specific protein" /codon_start=1 /product="claudin-11" /protein_id="NP_032796.1" /db_xref="CCDS:CCDS17290.1" /db_xref="GeneID:18417" /db_xref="MGI:MGI:106925" /translation="
MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"
misc_feature 234..296 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="propagated from UniProtKB/Swiss-Prot (Q60771.1); transmembrane region" misc_feature 246..746 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl21598" /db_xref="CDD:451326" misc_feature 477..539 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="propagated from UniProtKB/Swiss-Prot (Q60771.1); transmembrane region" misc_feature 597..659 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="propagated from UniProtKB/Swiss-Prot (Q60771.1); transmembrane region" misc_feature 702..764 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="propagated from UniProtKB/Swiss-Prot (Q60771.1); transmembrane region" misc_feature 807..809 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q99P82; propagated from UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site" misc_feature 810..812 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site" misc_feature 819..821 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site" misc_feature 822..824 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site" exon 457..621 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /inference="alignment:Splign:2.1.0" exon 622..1872 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" /inference="alignment:Splign:2.1.0" regulatory 1846..1851 /regulatory_class="polyA_signal_sequence" /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" polyA_site 1870 /gene="Cldn11" /gene_synonym="Claudin-11; Claudin11; Osp; Otm" ORIGIN
gagggggcggggacgcgctgcccagcagcgctgcagtcccctccaggcgcacctgtccccgctgcacgctgtcgcagcagtgcttgcagccgctctctccccatctcgagtagcccggagccagcggctcgcgagggccaagagggcaagcctagggaaggctctgtccaggacgacacagggggcacaatccgtgtgagtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgccttcaggtggtgggtttcgtcacgagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgaaaaatggacgaactgggctccaagggcctgtgggctgactgcgtcatggccactggtctctaccactgcaaacccctggtggacatcctcatccttccaggctacgtgcaggcttgtagagccctcatgattgctgcctccgttctgggcctgcccgccatcttgctgctgttgacagttctcccctgcatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgtgcccaccgcgagatcaccatcgtgagctttggctactcgctgtacgcaggttggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcatttggagaaaaccgtttctattactcttctggttccagctcgccaacgcatgccaagagtgcccatgtctaagagggctgctccactgcccgccgaggtgctgtaaatgctgggcctgggccctgggtttgctcgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgccccggcattttgaagtcgtaacaccccacccacccacccaccacttcttggctgccttaaaagaaagctctagctcagttaatgcccacatagttttctcctggagttgcgggctgtggctgtttgctctttcctcgggcattccattgttgttgattaaaaaaatattttgtttctctcttaaattcaaatgtcttgggaacattgctgacttgggtgtggattgggaaagaaataaaagatgcttttcaaagggttaccaacgacagtggaagccttatagagacagctctcttctccctttcggcttagtttcaaggtcacttatatataagagatagaaatggatagattgggaacacgggtgggaggggaactcagagctttccctccacgggaagcttctcttttataagttgaggggttgggtgtctttttttttttagtttgcgattttacatttttctgtacgtactttttcaagattgatcatttttataaccacgggtttcctgaaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataaataatagtacgaagattataactttaactgactgcccacggtttccaggtttgtatgctatagtttttaatcctatggttgcatatgcttcaaattaacacatttaaaaatcttttctccccttctatttctgtctccattctgttagagaccatgaagcagtattgtttaacataagttgtactgttaagtttggcttcatgggtgtaaacaccaatggtctgtcagtgtctaagactctggatactgcaagctccgtccggtgcatttgttcaggtaaaatctgtgcaataaaataacaaactgtctccaaagc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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