2024-05-15 12:35:38, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_007524 1437 bp mRNA linear ROD 02-MAY-2023 DEFINITION Mus musculus NK3 homeobox 2 (Nkx3-2), mRNA. ACCESSION NM_007524 VERSION NM_007524.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1437) AUTHORS Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I, Allgower C, Mulaw M, Zengerling F, Gunes C, Lickert H, Christoffels VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer L and Kleger A. TITLE TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration JOURNAL BMC Biol 21 (1), 55 (2023) PUBMED 36941669 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1437) AUTHORS Burganova G, Schonblum A, Sakhneny L, Epshtein A, Wald T, Tzaig M and Landsman L. TITLE Pericytes modulate islet immune cells and insulin secretion through Interleukin-33 production in mice JOURNAL Front Endocrinol (Lausanne) 14, 1142988 (2023) PUBMED 36967785 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1437) AUTHORS Sakhneny L, Mueller L, Schonblum A, Azaria S, Burganova G, Epshtein A, Isaacson A, Wilson H, Spagnoli FM and Landsman L. TITLE The postnatal pancreatic microenvironment guides beta cell maturation through BMP4 production JOURNAL Dev Cell 56 (19), 2703-2711 (2021) PUBMED 34499867 REFERENCE 4 (bases 1 to 1437) AUTHORS Oh HK, Park M, Choi SW, Jeong DU, Kim BJ, Kim JA, Choi HJ, Lee J, Cho Y, Kim JH, Seong JK, Choi BH, Min BH and Kim DW. TITLE Suppression of Osteoarthritis progression by post-natal Induction of Nkx3.2 JOURNAL Biochem Biophys Res Commun 571, 188-194 (2021) PUBMED 34330063 REMARK GeneRIF: Suppression of Osteoarthritis progression by post-natal Induction of Nkx3.2. REFERENCE 5 (bases 1 to 1437) AUTHORS Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gomez G and Constancia M. TITLE Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function JOURNAL PLoS Genet 16 (10), e1009069 (2020) PUBMED 33057429 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 1437) AUTHORS Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE and Izumo S. TITLE Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development JOURNAL Dev Genet 22 (3), 239-249 (1998) PUBMED 9621431 REFERENCE 7 (bases 1 to 1437) AUTHORS Yoshiura KI and Murray JC. TITLE Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia JOURNAL Genomics 45 (2), 425-428 (1997) PUBMED 9344671 REFERENCE 8 (bases 1 to 1437) AUTHORS Wightman PJ, Hayward BE and Bonthron DT. TITLE The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5 JOURNAL Mamm Genome 8 (9), 700-701 (1997) PUBMED 9271679 REFERENCE 9 (bases 1 to 1437) AUTHORS Chen X and Lufkin T. TITLE Linkage mapping of Sax2 to mouse chromosome 5 JOURNAL Mamm Genome 8 (9), 697-698 (1997) PUBMED 9271676 REFERENCE 10 (bases 1 to 1437) AUTHORS Tribioli C, Frasch M and Lufkin T. TITLE Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton JOURNAL Mech Dev 65 (1-2), 145-162 (1997) PUBMED 9256352 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U87957.1 and BC145874.1. On Nov 24, 2007 this sequence version replaced NM_007524.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC145872.1, BC021014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-5 U87957.1 1-5 6-1437 BC145874.1 1-1432 FEATURES Location/Qualifiers source 1..1437 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" /chromosome="5" /map="5 22.58 cM" gene 1..1437 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="NK3 homeobox 2" /db_xref="GeneID:12020" /db_xref="MGI:MGI:108015" exon 1..742 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /inference="alignment:Splign:2.1.0" misc_feature 82..84 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="upstream in-frame stop codon" CDS 277..1278 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="homeodomain protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1; bagpipe homeobox gene 1 homolog" /codon_start=1 /product="homeobox protein Nkx-3.2" /protein_id="NP_031550.2" /db_xref="CCDS:CCDS19259.1" /db_xref="GeneID:12020" /db_xref="MGI:MGI:108015" /translation="
MAVRGSGTLTPFSIQAILNKKEERGGLATPEGRPAPGGTEVAVTAAPAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVGQSAESPGGWDSDSALSEENEGRRRCADVPGASGTGRARVTLGLDQPGCELHAAKDLEEEAPVRSDSEMSASVSGDHSPRGEDDSVSPGGARVPGLRGAAGSGASGGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVAVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAGTQ"
misc_feature 496..639 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="propagated from UniProtKB/Swiss-Prot (P97503.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 685..912 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="propagated from UniProtKB/Swiss-Prot (P97503.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature order(895..909,913..915,964..966,982..984,1021..1023, 1027..1032,1039..1044,1048..1056,1060..1065) /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature 901..1065 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="Homeobox domain; Region: Homeobox; pfam00046" /db_xref="CDD:395001" misc_feature order(901..903,910..912,1030..1032,1039..1044,1051..1053) /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" exon 743..1437 /gene="Nkx3-2" /gene_synonym="Bapx1; Nkx-3.2; NKX3.2" /inference="alignment:Splign:2.1.0" ORIGIN
gaagagataatcggccgggctgtaggagaagagcatctggcgctggattccaggggagggggtcctggcgaggtgggcctgtgaggtggggtgagggtcggcgcggatcctggaactgaggggggcgggggctgctgtgctgcgcaggagtgggttgcgggggcctggcgcgcccctctcactcgcgctgaggtcgcccagagctccgtgtcaggctcgaagctgtccccgcgccccagttgccctcctggctgccggctccgatctgcggcgcagatggctgtgcgcggcagcggcaccttgacgcccttctccatccaggcgatcctcaacaagaaagaggagcgcggcgggttggctacgccggaggggcgcccggcaccagggggcacagaggtggcggtgaccgcggcgcccgccgtctgctgctggcggatcttcggggagaccgaggccggtgcgctggggggcgccgaggactctcttctggcatctcccgcccgaaccagaacagccgtggggcagagcgcagagagtccgggaggttgggactcagactcagccctgagcgaagagaacgagggcaggaggcgctgcgccgatgtcccgggagccagtggaaccggccgcgccagggtgaccctgggcctggaccagccaggctgcgagctgcacgccgccaaggacctggaggaggaagccccggtccgcagcgacagcgagatgtcagccagcgtttcaggcgaccacagcccgagaggcgaggatgacagcgttagccctggaggtgcacgcgtgcctgggttgcgcggcgccgcgggcagcggggctagcggcgggcaggcgggcggcgtggaggaggaggaagagcccgcagcccctaaaccgcgaaagaagcgctcccgggccgccttctcgcacgcccaggtcttcgagctggagcgccgctttaaccatcagcgctacctgtccgggccggagcgcgcagacctggcagcttcgctgaagctcacagagacgcaagtgaagatctggtttcagaaccgtcgctacaagaccaaacgccggcagatggccgccgacctgctcgcctctgcacccgccgccaagaaagtggccgtaaaggtgctggtgcgtgacgaccaaagacagtatttgcccggagaggtgctgaggccaccttcccttctgccactgcagccctcctactactacccttactactgtctcccgggctgggcgctgtccacgtgcgcggccgctgctggtacccagtgaagcccttgggacgaggcaaagaaggattcctgcgtcccccgtatgcaccgccacggacaggtgtactctgtgcaggcgagttctgctcaactggggatgaggcaggtggggaatgaaatcctgctgggacttgacacacctatccagggtgacagggcc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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