2024-05-15 11:36:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001407215 4279 bp mRNA linear ROD 23-NOV-2023 DEFINITION Mus musculus protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Pcmt1), transcript variant 31, mRNA. ACCESSION NM_001407215 VERSION NM_001407215.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 4279) AUTHORS Zhang C, Guo ZF, Liu W, Kazama K, Hu L, Sun X, Wang L, Lee H, Lu L, Yang XF, Summer R and Sun J. TITLE PIMT is a novel and potent suppressor of endothelial activation JOURNAL Elife 12, e85754 (2023) PUBMED 37070640 REMARK GeneRIF: PIMT is a novel and potent suppressor of endothelial activation. Publication Status: Online-Only REFERENCE 2 (bases 1 to 4279) AUTHORS Qin Z, Dimitrijevic A and Aswad DW. TITLE Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging JOURNAL Neurobiol Aging 36 (2), 1029-1036 (2015) PUBMED 25465735 REMARK GeneRIF: PIMT levels may significantly influence the course of age-related central nervous system dysfunction. REFERENCE 3 (bases 1 to 4279) AUTHORS Dimitrijevic A, Qin Z and Aswad DW. TITLE Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse JOURNAL PLoS One 9 (6), e100622 (2014) PUBMED 24955845 REMARK GeneRIF: Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse. Erratum:[PLoS One. 2014;9(12):e116556] Publication Status: Online-Only REFERENCE 4 (bases 1 to 4279) AUTHORS Qin Z, Yang J, Klassen HJ and Aswad DW. TITLE Isoaspartyl protein damage and repair in mouse retina JOURNAL Invest Ophthalmol Vis Sci 55 (3), 1572-1579 (2014) PUBMED 24550364 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 4279) AUTHORS Kapadia B, Viswakarma N, Parsa KV, Kain V, Behera S, Suraj SK, Babu PP, Kar A, Panda S, Zhu YJ, Jia Y, Thimmapaya B, Reddy JK and Misra P. TITLE ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis JOURNAL PLoS One 8 (12), e83787 (2013) PUBMED 24358311 REMARK GeneRIF: ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4279) AUTHORS MacLaren DC and Clarke S. TITLE Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene JOURNAL Genomics 35 (2), 299-307 (1996) PUBMED 8661142 REFERENCE 7 (bases 1 to 4279) AUTHORS Galus A, Lagos A, Romanik EA and O'Connor CM. TITLE Structural analysis of transcripts for the protein L-isoaspartyl methyltransferase reveals multiple transcription initiation sites and a distinct pattern of expression in mouse testis: identification of a 5'-flanking sequence with promoter activity JOURNAL Arch Biochem Biophys 312 (2), 524-533 (1994) PUBMED 8037467 REFERENCE 8 (bases 1 to 4279) AUTHORS Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ, Svenson KL, Sparkes RS and Lusis AJ. TITLE Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse JOURNAL Genomics 18 (2), 295-307 (1993) PUBMED 8288233 REFERENCE 9 (bases 1 to 4279) AUTHORS MacLaren DC, O'Connor CM, Xia YR, Mehrabian M, Klisak I, Sparkes RS, Clarke S and Lusis AJ. TITLE The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10 JOURNAL Genomics 14 (4), 852-856 (1992) PUBMED 1478665 REFERENCE 10 (bases 1 to 4279) AUTHORS Romanik EA, Ladino CA, Killoy LC, D'Ardenne SC and O'Connor CM. TITLE Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase JOURNAL Gene 118 (2), 217-222 (1992) PUBMED 1511895 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156391.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR14995048.2119050.1, SRR17253011.1196778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-522 AC156391.6 112794-113315 523-627 AC156391.6 127235-127339 628-659 AC156391.6 128769-128800 660-764 AC156391.6 131961-132065 765-885 AC156391.6 135575-135695 886-971 AC156391.6 136260-136345 972-1147 AC156391.6 138165-138340 1148-4279 AC156391.6 145414-148545 FEATURES Location/Qualifiers source 1..4279 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="10" /map="10 2.26 cM" gene 1..4279 /gene="Pcmt1" /gene_synonym="PIMT" /note="protein-L-isoaspartate (D-aspartate) O-methyltransferase 1" /db_xref="GeneID:18537" /db_xref="MGI:MGI:97502" exon 1..522 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" misc_feature 141..143 /gene="Pcmt1" /gene_synonym="PIMT" /note="upstream in-frame stop codon" misc_feature 294..296 /gene="Pcmt1" /gene_synonym="PIMT" /note="upstream_AUG_codon; putative N-terminal extension: MPGARIGGSGSDGSNSGRSSGDTSGAVTVWEVVSLLGKLLGTVAALKVVLYLLRVCFA " CDS 468..1160 /gene="Pcmt1" /gene_synonym="PIMT" /EC_number="2.1.1.77" /note="isoform 11 is encoded by transcript variant 31; protein-L-isoaspartate(D-aspartate) O-methyltransferase; protein-beta-aspartate methyltransferase; L-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase" /codon_start=1 /product="protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 11" /protein_id="NP_001394144.1" /db_xref="GeneID:18537" /db_xref="MGI:MGI:97502" /translation="
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKSNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKDDPMLLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSVKMKPLMGVIYVPLTDKEKQWSRWKDEL"
mat_peptide 471..1148 /gene="Pcmt1" /gene_synonym="PIMT" /product="Protein-L-isoaspartate(D-aspartate) O-methyltransferase. /id=PRO_0000111876" /note="propagated from UniProtKB/Swiss-Prot (P23506.3)" misc_feature 471..473 /gene="Pcmt1" /gene_synonym="PIMT" /note="N-acetylalanine. /evidence=ECO:0000250|UniProtKB:P22061; propagated from UniProtKB/Swiss-Prot (P23506.3); acetylation site" misc_feature 489..1115 /gene="Pcmt1" /gene_synonym="PIMT" /note="Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135" /db_xref="CDD:395902" exon 523..627 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 628..659 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 660..764 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 765..885 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 886..971 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 972..1147 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" exon 1148..4279 /gene="Pcmt1" /gene_synonym="PIMT" /inference="alignment:Splign:2.1.0" ORIGIN
gcggagcccaagaaggcggcacacgtcggacccgccatcccgcatcagccagagccgcggctaggaaggagcctcatcacgcagaacaccagctcgccggccgcaggacggaggcaggtgcaggcctcaggaaggggaactgagcagcgttcgtttgtgcgacctcgctgcggccaccgagcactggttatcgcccccgctcgctactgggctccaggactcccccgccgcgggccccgcctggccgcaccccggactgcgcggcgtcacagagcgcatgcgtgccgcgggggatgccgggagcgcgcattggcggcagtggcagcgacggcagtaacagcggccgctcgagcggggacaccagcggggcggtgaccgtgtgggaggtggtctcactcttggggaaactgctagggaccgtcgccgcgctgaaggtggttctgtacctgctccgggtgtgcttcgcgatggcctggaaatccggcggcgccagccactcggagctaatccacaacctccgcaagaatggaatcatcaagacagataaagtatttgaagtgatgctggctacagaccgttcccactatgcaaaatctaacccttacatggattctccacaatcaataggtttccaggcaacaatcagtgcccctcatatgcacgcatatgcactagaacttctgtttgaccagctgcatgaaggtgctaaagccctggacgtgggctctggaagtggaatcctcaccgcctgttttgcacggatggttggaaatagtggaaaagtcattggaattgatcacattaaagaactagtagatgactcaataactaatgtcaaaaaggatgacccaatgctcctgtcctcggggcgagtgcggctggtggtgggtgatggaagaatgggatacgctgaagaagccccttacgacgctattcatgtgggagctgcagccccagttgtgccccaggcattaatagaccagttaaagcctggtggaagattgatattgccagtcggtcctgcaggaggaaaccaaatgttggagcagtatgacaagctacaagatggcagtgtcaaaatgaaacctctcatgggggtgatatacgtgcctttaacagataaagaaaagcagtggtccaggtggaaggatgaactgtgaaagcaacgtgagcttgaccagtctataaaccgcagtgggccgctcctctcggtccttacagcatttgagaaccaacagcatcacagcttgttttggactttgttacactcttactttcagcatgaaaacgtgtggttttgtaggatttcctaattccaaacggcgcggagccaaactgatagaggaaggctgcagagcgttaactgcgtgtgttgttttaacatgcccacatttcactttaaaaaaatattaaaagaaagagttctccaactggaaaaattagttttgaagagtggctttgcttttcttgggcacttaattctgttccaatattaattcatcagatttattttgtgcatcagataacaccacattcacaagtttagcttctttggtagccaatgtctgttagatgctactaagaaaacagagatgagctttcttcttaaaagcctttgatgtggcgtcataggatagcatgtcgtagatacaatcagctgctgttaccttaaaactaggtgtttgtaaatactgaaacttgagacgacgatgatggcaggtggtgtcccaaaaacactcagctgttccgattggaaattttgatgtaaatttcctctctctaaaaatgctaggaggcttgtagctcaatatcatttatttgtttctagtttgctgctggtaatgtatctgcatctaacattctgtgtaagcggtcgtgtctttgcacagtttatgcagcgctgctttgccaaataaaattaaaagcaaaagaagcattggtggcctttgaatctagaaggacacaggtctgctaggtccagatgctgcccacagtcctggggaagcgtcgtagtcttatgatattctaggaggtagatatgcatagcattcgtccactctatgtggctgcatttcttcaggatggagactctgtgttcattgtttctctctgccttcctagcccaaggcttgctttttaatagctctgtagtaaatgctcaatgagtgactgggtgaatgtagtatgaggaagaatgtggttgagagtaaacatactgaaatccatgtctcatctataaatagattcattaatttaataactgtaaaatgtctgtgaaggcaatggcactttgaagatcttatttaaatatggttttatattttctaataagactttagttttttgtgaagatcctagaacttgagagaagattagaagctcccggtaaatggggctaagcaaagcgaagccttccctctatgtgtaagggcacatgattctgacaagaagactcttagtgtctgagaagcccatccccactcttcacatcttaaattactgatttaaaagtcatgcagacatcacctgacaagtgtctcttcttggcttaggtctcagtcccaggaaactagcattactgtggtcccgcagacttgaaaaccttaaccagctttggtttgctgctggttgttgctttggaatcctgtcagtgaccccctggagtccaggatgcatggtcatttgaaatatgtgtaaagtcaaatgttcactcaggctttaaagcaaataaattcttaaacttacccaccagtctggatccttggtagtcattgcacattacagcacgcaaatctctgtgctgggcttcaggacggaagaggtgcttccaggtcagtttgccgtccagtggcggggacagtttataaataggcaccatacacttcacccagtttgtacagaaactctgtgcccaagccttgctcttagacttgacacttttaggaggtgaaactttaggatgttgaatgaacagccagtttgaacagcagcactaagtgggtagagatagaagaatggtgttaatgaggtctaagccctttaaaagagttgaatttatatatgtgtttaagacaggtaagaaatgcctgattttcagtgtgcataatttccagagcattttattttcctcatagaaagtacatctgaatacacataatgtaaagggcaatgaagatacttcgagtcattataggtagtgtgatcttgtgaataaactcttcctataaatttgctcttcctagaagctaaatctagttgtcagacttgggttgcagcaataagcttatgtcagggttgagtttctcttcagggctgcttgctctttcccagccaggaacaggacaaatcggcacccagggaaataactactactggccacaccaatacttaggacttcatcccccttgcagctgccatgttttattgtttgtttgtttatttgtggcaggtgggggtggatagcaagatggctcggggtaaagaggcttgctgccaaacctgaagacctgagtttcacccctcccccctcccagacccacagagtagaaggacagctgacacctgcagattgttctctgaccttcaggcatggtagcacttgcctgaaatcccagcacttggaagcaggaagggtcagaagtcatcctaggttacacaagttcaaggccagcccgaatttcatgagagcctgccttaaaggaaagaaaaaaccaaaaagtttctacagtgcatctcttcactaaagcatcgtaagcattgagtggattctaaaggagccatttttaaagtaataactttgtaaactcttcaagctgttcttgaaggaattcctcagagtgtttaaggccttttatctctctagagttttctaatttctggtagtttagtgtggcatcaaagaaagtcatgacagtgttgtcacccagcactgatagacaaatagtaagcatgagtcatcttataaattgttgtagaactcaaccggctgataacttattttaggtaagcacttaaactcttgtagcatacagatcatttcttatcgaatgctgtgttcctgatgccctaatatcttaatgtattctgtagtggagatgggccctgactggactttggttgcatctctgagcttccaccatctttcagaaagatggtagtattttgcccttagcattgttaaaggttctcactcagtaaggggacccacttgaaaagggtactggcccaaggaagcctgggactgtgcactggaatataataaagtggaaatgaagtctaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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