LOCUS       XM_053697506            2949 bp    mRNA    linear   VRT 04-MAR-2023
DEFINITION  PREDICTED: Bombina bombina dicer 1, ribonuclease III (DICER1),
            transcript variant X4, mRNA.
ACCESSION   XM_053697506
VERSION     XM_053697506.1
DBLINK      BioProject: PRJNA925521
KEYWORDS    RefSeq.
SOURCE      Bombina bombina (fire-bellied toad)
  ORGANISM  Bombina bombina
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Bombinatoridae; Bombina.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_069499) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_027579735.1-RS_2023_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/03/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2949
                     /organism="Bombina bombina"
                     /mol_type="mRNA"
                     /isolate="aBomBom1"
                     /db_xref="taxon:8345"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="blood, muscle, kidney, liver"
                     /dev_stage="adult"
                     /country="Poland: Ksiaz Wielki"
                     /lat_lon="50.433333 N 20.150000 E"
                     /collection_date="2020-08"
     gene            1..2949
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     Proteins"
                     /db_xref="GeneID:128644874"
     CDS             374..2833
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X4"
                     /protein_id="XP_053553481.1"
                     /db_xref="GeneID:128644874"
                     /translation="

MPGIMQSLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQIELLEAAMDHNTIVCLNSGSGKTFIAVLLTKELSYQIRGDFNSDAKRTVFLVNSAKQVDHQVSTIRTHSDLKVGEYSDIELAESWTKEKWNQEFVDRQVLVMTCHIFLKVLKNGILSLLKINLLVFDECHLAIQEHPYQEIMKICESSQTCPRILGLTASILNGKCDPFDLEEKIQKLERILKSNAETATDLVVLDRYASQPCEIVLDCGSFIDKSGLYQRLLSEVDDALHFLDDCNISSLSRERDSILISKQILSDCRAVLLVLGPWCADKVAGMMVRELQKYIKHEQELLHRKFLLFTDTILRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEEDDDEDEEIEEKEKTETCFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLSDSERIKDFEEDLKTYKAIEKILRNKCSKSLDSGETESDPVVDDDEILPPYVLRQDDGSPKVTINTAIGHINRYCARLPSDPFTHLAPKCKTRELNDGHFRSTLYLPINSPLRAPIVGPSMNCARLAERAVALICCQKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETNVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYSPEDTTRCFGILTAKPIPQHWIGHWT"

     misc_feature    494..1087
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(494..505,512..514,563..586,707..709,896..898,
                     989..991)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(671..676,743..748,821..823,827..832,839..841,
                     914..922)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1181..1465
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1196..1201,1208..1210,1214..1219,1394..1399,
                     1406..1411,1418..1420,1427..1432,1439..1441)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1484..2062
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1718..1726,1934..1936,1991..1993,1997..1999)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1946..1948,1952..1954,2027..2029,2033..2035)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2261..2527
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:427264"
     polyA_site      2949
                     /gene="DICER1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

ggtcgggcccgttctgcgccgcactttcctcttagaagccgtgtttcagaacccgacagcgggttgctttattgtatacatcgagccgagcatgggggaggagcccgacagcccggccacatagacacaccatacaggaagcaggcagcagacccctggcaccgacttcacctgctggttgccaagggtgagttaccgatttttggaatctctagcaatgcgacagagacccatgaagactaagatttgattatctacatgcagatatggtgtcacagtgccgttcatcagtcagtcgttcaaaaatctctgctattgaaacgtgagctgcgcagaaggaaaattgcaatgatctaattcactggatgtatgaatgcccggcattatgcagtctctcagcatggcaggcctgcaacttatgacccctgcctcatcaccaatgggccccttctttgggttgccatggcaacaagaagccattcatgataacatttataccccaaggaaatatcagattgaactgctggaagctgcaatggatcacaatactatagtttgtttgaactctggctcagggaagacttttattgcagtactactcactaaagagctgtcttaccagatacgtggagattttaacagtgatgctaagaggacagtatttttggtcaactctgctaaacaagttgatcatcaagtgtctacgatcaggactcattctgatttaaaagtgggggaatattcagacatagaactagcagaaagctggacaaaagagaaatggaaccaagagtttgtagatcgtcaggtattggtcatgacgtgccacatattcttaaaagttctgaaaaacggaatcttatctttgttgaaaattaacttgttggtatttgacgaatgtcatcttgcaatccaggaacatccatatcaggaaatcatgaagatctgtgagagttcccagacttgtcctagaatcttgggattgactgcttcaatattgaacgggaaatgtgatccttttgacctggaagagaagatccagaaactggagagaattctgaagagtaatgcagaaactgcaacagatctagttgttttagacagatatgcgtctcagccatgtgaaattgttttggattgcggatcattcatcgataaaagtggactttatcaaagacttttaagtgaagtggatgatgcacttcattttcttgatgactgtaatatttcttcactatcacgagaaagagattctatattaatttctaaacagattctgtcagactgtagagcagttcttttggttctgggtccgtggtgtgccgataaagttgcaggaatgatggtgagagagctacagaaatacataaaacatgagcaggagttgctgcacaggaaattcctactgtttacagacactattttaaggaaaatccatgctctctgtgaagagcacttctcacctgcctcacttgatctgaaatttgtcacccctaaagtcataaaattgctagagattctgcggaaatacaaaccttatgagcggcagcaatttgagagtgtcgagtggtataacaataggaatcaggataactatgtgtcttggagcgattctgaggaggatgatgatgaagacgaagagattgaggaaaaagagaaaaccgaaacatgcttcccctcgccgtttacaaatattttatgtggcatcatctttgtggaaagacgatacacagcagttgttctcaacaggttgataaaggaagctgggaaacaagaccctgaacttgcttacattagtagcaactttataactggacatggtattgggaagaaccagccacgtaataaacagatggaagtggagttccgaaaacaagaagaggttcttcgaaagttcagagcgcatgagaccaacttactcatagctaccagcattgtagaagagggtgtagacataccaaaatgtaacttggtggttcggtttgacttgccttcagaatacagatcctatgttcaatctaaaggaagagcgagagctcccatctcaaattacatcatgttgtcagactctgaaagaataaaggattttgaagaagatcttaaaacatataaagcaattgaaaagattttgcgaaataaatgctccaaatccctggattctggggaaactgagtctgaccctgttgtcgatgatgatgaaatattgccaccctatgtgttgcgacaagatgatggtagtccaaaggttactattaacaccgctattggacacatcaataggtattgcgctaggttacctagcgacccattcactcatcttgctccaaaatgtaaaacccgagaattgaatgatggacatttccgctcaacactctacctgcccatcaactctcctctccgtgctcccattgttggaccttcaatgaactgtgccagattagcagagagagcagtggctcttatatgctgccagaaattgcatgagataggtgaactagatgatcatttgatgccagttggaaaagaaactgttaaatatgaagaggaactggatttacatgatgaggaagaaaccaatgttcccggcagaccaggctctacaaaaagaaggcagtgctatcctaaagctattccagaatgtttgcggaatagctacccaaaacctggtcagccatgttatttgtatgtgataggaatggtgttaaccacccctctgccagacgagctaaattttaggaggcggaaactgtattcccctgaagacaccaccagatgctttggaattctcacagccaaacctatacctcagcattggattggacattggacctagaagctttgatgacatctttttgattaattactggaaacatccctcttgactttgataatttttcttttggcttttgtgtcagatctactaataaagctatccggcagtgcaactta

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