LOCUS       XM_047736081            2613 bp    mRNA    linear   MAM 04-MAR-2023
DEFINITION  PREDICTED: Lutra lutra dicer 1, ribonuclease III (DICER1),
            transcript variant X3, mRNA.
ACCESSION   XM_047736081
VERSION     XM_047736081.1
DBLINK      BioProject: PRJNA824478
KEYWORDS    RefSeq.
SOURCE      Lutra lutra (Eurasian river otter)
  ORGANISM  Lutra lutra
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Musteloidea; Mustelidae; Lutrinae; Lutra.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_062284) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_902655055.1-RS_2023_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/03/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Lutra lutra"
                     /mol_type="mRNA"
                     /db_xref="taxon:9657"
                     /chromosome="7"
     gene            1..2613
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     Protein, and 99% coverage of the annotated genomic feature
                     by RNAseq alignments, including 24 samples with support
                     for all annotated introns"
                     /db_xref="GeneID:125103969"
     CDS             373..2613
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X2"
                     /protein_id="XP_047592037.1"
                     /db_xref="GeneID:125103969"
                     /translation="

MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVGQQVSAVRTHSDLKVGEYSNLEVNASWTKEKWNQEFAKHQVLVMTCSVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYGRLLVELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVQRRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIEPVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAVSIG"

     misc_feature    466..1059
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(466..477,484..486,535..558,679..681,868..870,
                     961..963)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(643..648,715..720,793..795,799..804,811..813,
                     886..894)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1159..1437
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1168..1173,1180..1182,1186..1191,1366..1371,
                     1378..1383,1390..1392,1399..1404,1411..1413)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1456..2034
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1687..1695,1903..1905,1960..1962,1966..1968)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1915..1917,1921..1923,1996..1998,2002..2004)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2230..2496
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:427264"
ORIGIN      

gaggcgacggcgagcgggaggaaatggcggcggcggcggcggcgccaggcggcaccgggaggcctgggctgtgacgcgcgcgccggagcggggtccgatggttctcgaaggcccgcggcgccccgtgctgcaggttacctagggtatgaattaatacagacttggaaactgaaagaacttagaatcagcattttgagagcagaagcttgggcatgctgtgattttccaataaaccgctatcacaatgtcaaagtgcagttcagacaacagcaacacagagatctcaaacattaacacgtaagctgtgctagagcagaaggcaatgaaagaagcactggatgagtgaaaagctctgctttgcagccgctcagcatggcaggcctgcagctcatgacccccgcctcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttacacgccaagaaaatatcaggttgaactgcttgaagcagctctggatcataacaccatcgtctgtttaaacactggctcagggaagacgtttattgcagtactactcactaaagagctgtcctatcagatcaggggagacttcaacagaaatggaaaaaggacggtgttcttggtcaactctgcaaaccaggttggtcaacaagtgtcagctgtcagaacgcattcagatctcaaggttggggaatactcaaacctagaagtaaacgcatcttggacaaaagagaaatggaaccaagagtttgctaagcaccaggttctcgttatgacttgctctgtcgccttgaatgttttgaaaaatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgcaattctagaccacccctaccgagaaattatgaagctctgtgaaaattgtccgtcgtgtcctcgtattttgggactgactgcttccattttaaatgggaaatgcgatcctgaggaattggaagaaaagattcagaaactggagaaaattctgaagagtaatgctgaaaccgcaactgacctggtggtcttggacagatacacttctcaaccgtgtgagatcgtggtagactgtgggccatttacggacaggagtggcctctacggcagactgctggtggagctagaggaagcacttaactttatcaacgactgtaacatatctgtgcattcgaaggaaagagattctactttaatttctaaacagatcctctcggactgtcgtgcagtcctggtggttctgggcccctggtgtgcagataaagtcgctgggatgatggtaagagaattgcagaaatacatcaagcacgagcaagaggagctgcacaggaaatttctcttgtttacagacaccttcctgaggaaaatacacgctctgtgtgaagagcacttctctcctgcctcccttgacctgaaatttgtgactcctaaagtaataaaactccttgaaatcttacgcaaatacaaaccgtacgagcggcagcagtttgagagtgttgagtggtacaataatcggaaccaggataattatgtgtcttggagtgattctgaggacgatgatgaggatgaagaaatcgaagaaaaggaaaagccggagacaaattttccttctccgtttaccaatattttatgcggaatcatttttgtgcaaagaagatacacagctgttgtcttaaacagattgataaaggaagctggcaaacaagatccagagctggcttacatcagcagcaattttataactggacatggcatcggaaagaatcagcctcgtaacaaacagatggaagccgagttcagaaaacaggaagaggtccttaggaaatttcgagcacatgagaccaacctcctcattgcaacaagtattgtggaagagggtgttgatataccaaagtgcaacttggtggttcgatttgatttgcccacagagtatcgatcctatgttcaatctaaaggaagagcaagggcaccgatctctaattatataatgttagcggatacagacaaaataaaaagttttgaagaagacctgaaaacatacaaagctattgaaaagatcttgagaaacaagtgttccaagtcagttgacactggagagactgacattgaacctgttgtagatgatgatgatgtgttcccaccatacgtgttgaggcctgatgatggtggtccacgagtcacaatcaacacggctattggacacatcaatagatactgtgctagattaccaagtgacccgttcactcatctagctcctaaatgtagaacccgagagttgcctgatggtacattttattcaactctttatctgccaattaactcacctctccgagcctccattgttggtccaccaatgagctgtatccgattggccgaaagagttgtagctctcatctgctgtgaaaaactgcacaaaattggggaactggatgaccatttgatgccagttgggaaagaaactgttaaatatgaggaagagcttgatttacatgatgaagaagagaccagtgttccaggaagaccaggttccacaaaacgaagacagtgctaccctaaagcagttagtattggttag

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