LOCUS       NM_053153               1239 bp    mRNA    linear   ROD 18-FEB-2022
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            18 (Klra18), mRNA.
ACCESSION   NM_053153
VERSION     NM_053153.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS,
            Brown EG and Makrigiannis AP.
  TITLE     Influenza Virus Targets Class I MHC-Educated NK Cells for
            Immunoevasion
  JOURNAL   PLoS Pathog 12 (2), e1005446 (2016)
   PUBMED   26928844
  REMARK    GeneRIF: Data suggest Ly49:Ly49r interactions play critical role in
            influenza virus A host/pathogen interactions including immune
            evasion; knockout mice with natural killer cells lacking Ly49
            survive influenza A infection; Ly49r restores susceptibility.
            Erratum:[PLoS Pathog. 2016 Nov 4;12 (11):e1006021. PMID: 27814389]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Schenkel AR, Kingry LC and Slayden RA.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis
            AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL and Vidal SM.
  TITLE     Epistasis between mouse Klra and major histocompatibility complex
            class I loci is associated with a new mechanism of natural killer
            cell-mediated innate resistance to cytomegalovirus infection
  JOURNAL   Nat Genet 37 (6), 593-599 (2005)
   PUBMED   15895081
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Makrigiannis AP, Pau AT, Saleh A, Winkler-Pickett R, Ortaldo JR and
            Anderson SK.
  TITLE     Class I MHC-binding characteristics of the 129/J Ly49 repertoire
  JOURNAL   J Immunol 166 (8), 5034-5043 (2001)
   PUBMED   11290784
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF288377.1.
            
            On Apr 6, 2007 this sequence version replaced NM_053153.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288377.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AF288377.1         1-1239
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/J"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6"
     gene            1..1239
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 18"
                     /db_xref="GeneID:93970"
                     /db_xref="MGI:MGI:2136935"
     misc_feature    82..84
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /note="upstream in-frame stop codon"
     CDS             145..936
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /codon_start=1
                     /product="killer cell lectin-like receptor, subfamily A,
                     member 18"
                     /protein_id="NP_444383.1"
                     /db_xref="GeneID:93970"
                     /db_xref="MGI:MGI:2136935"
                     /translation="

MTEQKDTFSAVRFHKSSGLQNEMRLKETRKPRKAGLRVCSVPWQFIVIALGILISLRLVIVAVLMTNIFQYGQQKHELQEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESINRDQNRLYNKTKTVLDSLQHTGRGVKVYWFCYGMKCYYFIMDRKPWSRCKQSCQNSSLTLLKIDNEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH"

     misc_feature    262..606
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:429969"
     misc_feature    571..912
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(727..729,808..810,862..864,868..873)
                     /gene="Klra18"
                     /gene_synonym="Ly49r"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
ORIGIN      

gcctctaaggggatacagaccaggaaaggcccacattacgccaacagggacatccattccttctacccacctcacttcaggtagagtcacagaaatcactcaaggacatattttaaaagagaacatactctacatactcccaagatgactgaacagaaagacactttctcagctgtgagattccataagtcttcagggttgcagaacgagatgaggctcaaggagacacggaagcctcgaaaagctggcctcagagtgtgttcagttccctggcagttcattgtgatagctctcggaatcctcatttcccttcgactggtaattgttgcagtgcttatgacaaacatttttcagtatggtcaacaaaaacatgaactgcaggaatttctaaaacaccacaataactgcagcatcatgcaaagtgacatcaacttgaaggatgaactgctgaaaaataagtctatagagtgtaatcttctggaatccatcaacagggatcagaacagattgtataataaaaccaagactgttttagattccttacagcacacaggcagaggtgttaaagtatactggttctgttatggtatgaaatgttattatttcatcatggacagaaaaccatggagtagatgtaaacagagctgccagaattccagcttaacccttctgaagatagacaatgaggatgaactgaagttccttcagctcgtggtaccttcagacagttgctggattgggttgtcatatgataataagaaaaaagattgggcatggattgacaatcgcccatctaaacttgccttgaacacaacgaaatacaatataagagatggaggatgtatgttcttatctaaaactagactagacaataattactgtgatcaatcattcatctgtatttgtgggaagagattggacaaattccctcattgactctccagtgagtcttaaaagtaaaaaaaaatgaaattttctgactctcatttgtttcctgtaataattcatgactccttagaaacaagtgttttgaccattggacttagtctgcagtgcaaagagagagacactctggaagattttgggaatgttctctgaaacatgacatgaaagagcagaggacatcttccttccctgtggagactggacagatcttctctggtcccgcaaaacttgaatgaatctgatttatttgtttgcataaactccaatagaattaaataaaaaaaccttaataac

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