LOCUS       NM_053151               1150 bp    mRNA    linear   ROD 16-FEB-2022
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily A, member
            21 (Klra21), mRNA.
ACCESSION   NM_053151 XM_003945727 XM_006536421
VERSION     NM_053151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Rahim MM and Makrigiannis AP.
  TITLE     Ly49 receptors: evolution, genetic diversity, and impact on
            immunity
  JOURNAL   Immunol Rev 267 (1), 137-147 (2015)
   PUBMED   26284475
  REMARK    Review article
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Schenkel AR, Kingry LC and Slayden RA.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Corbett AJ, Coudert JD, Forbes CA and Scalzo AA.
  TITLE     Functional consequences of natural sequence variation of murine
            cytomegalovirus m157 for Ly49 receptor specificity and NK cell
            activation
  JOURNAL   J Immunol 186 (3), 1713-1722 (2011)
   PUBMED   21187440
  REMARK    GeneRIF: A recombinant murine cytomegalovirus in which m157(K181)
            is replaced with m157(G1F), which interacts with both Ly49H and
            Ly49C, causes no apparent attenuating effect on viral clearance
            from natural killer (NK) cells.
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Geurs TL, Zhao YM, Hill EB and French AR.
  TITLE     Ly49H engagement compensates for the absence of type I interferon
            signaling in stimulating NK cell proliferation during murine
            cytomegalovirus infection
  JOURNAL   J Immunol 183 (9), 5830-5836 (2009)
   PUBMED   19828630
  REMARK    GeneRIF: Signaling through the natural killer (NK) cell activation
            receptor Ly49H is able to compensate for the absence of cytokine
            stimulation in the preferential phase of viral-induced
            proliferation during murine cytomegalovirus infection.
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis
            AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL and Vidal SM.
  TITLE     Epistasis between mouse Klra and major histocompatibility complex
            class I loci is associated with a new mechanism of natural killer
            cell-mediated innate resistance to cytomegalovirus infection
  JOURNAL   Nat Genet 37 (6), 593-599 (2005)
   PUBMED   15895081
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Makrigiannis AP, Pau AT, Saleh A, Winkler-Pickett R, Ortaldo JR and
            Anderson SK.
  TITLE     Class I MHC-binding characteristics of the 129/J Ly49 repertoire
  JOURNAL   J Immunol 166 (8), 5034-5043 (2001)
   PUBMED   11290784
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF288380.1.
            
            On or before Jan 5, 2014 this sequence version replaced
            XM_006536421.1, XM_003945727.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288380.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/J"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6"
     gene            1..1150
                     /gene="Klra21"
                     /gene_synonym="Klra-ps1; Ly49H; Ly49u"
                     /note="killer cell lectin-like receptor subfamily A,
                     member 21"
                     /db_xref="GeneID:93968"
                     /db_xref="MGI:MGI:2136938"
     CDS             113..913
                     /gene="Klra21"
                     /gene_synonym="Klra-ps1; Ly49H; Ly49u"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily A,
                     member 21"
                     /protein_id="NP_444381.1"
                     /db_xref="GeneID:93968"
                     /db_xref="MGI:MGI:2136938"
                     /translation="

MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQLIVIALGILCSLRLVIVAVFVTKIFQYSQHKQEINETLNHHHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQDRWDSETKTVLHSTQNTGRGVKYWFCYSTKCYYFIMNKTTWSGCKANCQHYSVPIVNIEDKDELKFLQRHVITEGYWIGLSYDKKKKEWAWIDNGQSKLDMKIRKMNFKSRGCVFLSKARIEDTDCNIPYYCICGKKLDKFPD"

     misc_feature    230..583
                     /gene="Klra21"
                     /gene_synonym="Klra-ps1; Ly49H; Ly49u"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:429969"
     misc_feature    545..889
                     /gene="Klra21"
                     /gene_synonym="Klra-ps1; Ly49H; Ly49u"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(704..706,785..787,839..841,845..850)
                     /gene="Klra21"
                     /gene_synonym="Klra-ps1; Ly49H; Ly49u"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
ORIGIN      

aggggataacagaccagtaaaggcccacattaccccaattgaggcatccatcctttctacaggcatcacttcagggtggagacacagaacatacctctacttatcccataagatgagtgagcaggaggtcactttcccaactatgagattccacaagtcttcagggttgaacagccaggtgagacttgaggggactcagagatctagaaaagctggcctaagagtgtgttcagtcccttggcagctcattgtgatagcacttggaatcctctgttcccttcggctggtaattgttgcagtgtttgtgacaaagatttttcagtatagtcaacacaaacaagaaatcaatgaaactctcaaccaccaccataactgcagcaacatgcaaagggatttcaacttaaaggaagaaatgttgacaaataagtctatagattgtaggccaagctatgaacttctggaatacatcaaaagagaacaggacagatgggacagtgaaaccaagactgttttacattccacacagaacacaggcagaggtgttaaatactggttctgctatagtactaaatgttattatttcatcatgaacaaaactacatggagtggatgtaaagcgaactgccagcattacagcgttcccattgtgaacatagaagataaagatgaactgaaattccttcagcgccatgttattacagagggttactggattggattgtcttatgataagaaaaaaaaggaatgggcatggattgacaatggccaatctaaacttgacatgaaaataaggaaaatgaactttaagtctagaggatgtgtatttttatctaaagcaagaatagaagatactgactgtaatattccctactactgtatttgtgggaagaaactggataaattccctgattaactttccaaccagagttaaagaacatagtctgctgtgaagagaaacaaagctgcaagaacattgggactgtcctctcgacctatcttgacagaacagaggtcattttctatcctgttggagagaggacgcatctactcgggtgaatgtgcacgctttgccctaaagccttcagaactgtgttctttctgatttcttaaactcccataaaactgaataaagagtcccccctaaaataac

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