LOCUS       NM_013793               1083 bp    mRNA    linear   ROD 10-MAR-2022
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            15 (Klra15), mRNA.
ACCESSION   NM_013793 XM_003945723 XM_003945724 XM_003945725 XM_003945726
VERSION     NM_013793.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Wight A, Mahmoud AB, Scur M, Tu MM, Rahim MMA, Sad S and
            Makrigiannis AP.
  TITLE     Critical role for the Ly49 family of class I MHC receptors in
            adaptive natural killer cell responses
  JOURNAL   Proc Natl Acad Sci U S A 115 (45), 11579-11584 (2018)
   PUBMED   30249666
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS,
            Brown EG and Makrigiannis AP.
  TITLE     Influenza Virus Targets Class I MHC-Educated NK Cells for
            Immunoevasion
  JOURNAL   PLoS Pathog 12 (2), e1005446 (2016)
   PUBMED   26928844
  REMARK    Erratum:[PLoS Pathog. 2016 Nov 4;12 (11):e1006021. PMID: 27814389]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Rahim MM and Makrigiannis AP.
  TITLE     Ly49 receptors: evolution, genetic diversity, and impact on
            immunity
  JOURNAL   Immunol Rev 267 (1), 137-147 (2015)
   PUBMED   26284475
  REMARK    Review article
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Lima PD, Tu MM, Rahim MM, Peng AR, Croy BA and Makrigiannis AP.
  TITLE     Ly49 receptors activate angiogenic mouse DBA(+) uterine natural
            killer cells
  JOURNAL   Cell Mol Immunol 11 (5), 467-476 (2014)
   PUBMED   24954223
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Schenkel AR, Kingry LC and Slayden RA.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Belanger S, Tu MM, Rahim MM, Mahmoud AB, Patel R, Tai LH, Troke AD,
            Wilhelm BT, Landry JR, Zhu Q, Tung KS, Raulet DH and Makrigiannis
            AP.
  TITLE     Impaired natural killer cell self-education and 'missing-self'
            responses in Ly49-deficient mice
  JOURNAL   Blood 120 (3), 592-602 (2012)
   PUBMED   22661698
  REMARK    Erratum:[Blood. 2013 Oct 3;122(14):2525]
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Makrigiannis AP, Pau AT, Saleh A, Winkler-Pickett R, Ortaldo JR and
            Anderson SK.
  TITLE     Class I MHC-binding characteristics of the 129/J Ly49 repertoire
  JOURNAL   J Immunol 166 (8), 5034-5043 (2001)
   PUBMED   11290784
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Mehta IK, Smith HR, Wang J, Margulies DH and Yokoyama WM.
  TITLE     A 'chimeric' C57l-derived Ly49 inhibitory receptor resembling the
            Ly49D activation receptor
  JOURNAL   Cell Immunol 209 (1), 29-41 (2001)
   PUBMED   11414734
  REMARK    Erratum:[Cell Immunol 2001 Sep 15;212(2):158]
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Makrigiannis AP, Gosselin P, Mason LH, Taylor LS, McVicar DW,
            Ortaldo JR and Anderson SK.
  TITLE     Cloning and characterization of a novel activating Ly49 closely
            related to Ly49A
  JOURNAL   J Immunol 163 (9), 4931-4938 (1999)
   PUBMED   10528196
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Feldmeyer D, Kask K, Brusa R, Kornau HC, Kolhekar R, Rozov A,
            Burnashev N, Jensen V, Hvalby O, Sprengel R and Seeburg PH.
  TITLE     Neurological dysfunctions in mice expressing different levels of
            the Q/R site-unedited AMPAR subunit GluR-B
  JOURNAL   Nat Neurosci 2 (1), 57-64 (1999)
   PUBMED   10195181
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF146571.2.
            
            On or before Oct 10, 2012 this sequence version replaced
            XM_003945723.1, XM_003945724.1, XM_003945725.1, XM_003945726.1,
            NM_013793.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146571.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/J"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6"
     gene            1..1083
                     /gene="Klra15"
                     /gene_synonym="Ly49O"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 15"
                     /db_xref="GeneID:27423"
                     /db_xref="MGI:MGI:1351665"
     CDS             1..789
                     /gene="Klra15"
                     /gene_synonym="Ly49O"
                     /codon_start=1
                     /product="killer cell lectin-like receptor, subfamily A,
                     member 15"
                     /protein_id="NP_038821.2"
                     /db_xref="GeneID:27423"
                     /db_xref="MGI:MGI:1351665"
                     /translation="

MSEQEVTYSMVRFHKSAGLQKQVRPEETKGPREAGYRRCSFHWKFIVIALGIFCFLLLVAVSVLAIKIFQYDQQKKLQEILNHHNNCSNMQSDINLKDELLKNKSIECDLLESLNRDQNRLYNKTKTVLDSLKHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLFLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIENGPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH"

     misc_feature    118..459
                     /gene="Klra15"
                     /gene_synonym="Ly49O"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:429969"
     misc_feature    424..765
                     /gene="Klra15"
                     /gene_synonym="Ly49O"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(580..582,661..663,715..717,721..726)
                     /gene="Klra15"
                     /gene_synonym="Ly49O"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
ORIGIN      

atgagtgagcaggaggtcacttattcaatggtgagatttcataaatctgcaggattgcagaaacaagtgagacctgaggagactaaagggcccagagaagctggctacagaaggtgttcattccactggaagttcattgtgatagctcttggcatcttctgtttccttcttctggtagctgtttcagtgttggcaataaaaatttttcagtatgatcaacaaaaaaaactgcaggaaattctaaaccaccacaataactgcagcaacatgcaaagtgacatcaacttgaaggatgaactgctgaaaaataagtccatagagtgtgatcttctggaatccctcaacagggatcagaacagattgtataataaaaccaagactgttttagattccttaaagcacacaggcagaggtgttaaagtatactggttctgctatggtatgaaatgttattatttcgtcatggacagaaaaccatggagtagatgtaaacagagctgccagaattccagcttattccttctgaagatagacgatgaggatgaactgaagttccttcagctcgtggttccttcagacagttgctggattggattgtcatatgataataagaaaaaagattgggcatggattgaaaatggcccatctaaacttgccttgaacacaacgaaatacaatataagagatggaggatgtatgttcttatctaaaactagactagacaataattactgtgatcaatcattcatctgtatttgtgggaagagattggacaaattccctcattgactctctgacaagtgttaaaggtaaaaaaatgaatttttctgactctcatttgtttcctgtgataattcatgactccttacaagcaagtgttttgaccattggacttagactgcagtgcaaagagagagacaatctggaagattttgggaatgttctctgaaacatgacatgacagagcagaggacatcttcattccttgtggagactaaacagatcttctctggtcccccaatgcttggatgaatctgttttatttgtttgcatatactccaataaaagtaaataaagatcctt

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